Тренболон цена инструкция по применению

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Clinical data
Trade names	Finajet, Finaplix, others
Other names	RU-1697; Trenbolone 17β-acetate; 19-Nor-δ9,11-testosterone 17β-acetate; Estra-4,9,11-trien-17β-ol-3-one 17β-acetate
Routes of administration	Intramuscular injection
Drug class	Androgen; Anabolic steroid; Androgen ester; Progestogen
Pharmacokinetic data
Elimination half-life	Intramuscular: 3 days[1]
Identifiers
IUPAC name [(8S,13S,14S,17S)-13-Methyl-3-oxo-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
CAS Number	10161-34-9
PubChem CID	66359
DrugBank	DB14660
ChemSpider	17468428
UNII	RUD5Y4SV0S
ChEMBL	ChEMBL1698011
CompTox Dashboard (EPA)	DTXSID2046626
ECHA InfoCard	100.030.380
Chemical and physical data
Formula	C20H24O3
Molar mass	312.409 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)O[C@H]1CC[C@@H]2[C@@]1(C=CC3=C4CCC(=O)C=C4CC[C@@H]23)C
InChI InChI=1S/C20H24O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h9-11,17-19H,3-8H2,1-2H3/t17-,18+,19+,20+/m1/s1 Key:CMRJPMODSSEAPL-FYQPLNBISA-N

Trenbolone acetate, sold under brand names such as Finajet and Finaplix among others, is an androgen and anabolic steroid (AAS) medication which is used in veterinary medicine, specifically to increase the profitability of livestock by promoting muscle growth in cattle.^[2][3][4][5] It is given by injection into muscle.^[5][2]

Side effects of trenbolone acetate include symptoms of masculinization like acne, increased body hair growth, scalp hair loss, voice changes, and increased sexual desire.^[5] The drug is a synthetic androgen and anabolic steroid^[6] and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).^[5][2][7] It has strong anabolic effects and highly androgenic effects, as well as potent progestogenic effects, and weak glucocorticoid effects.^{[5][2][7][8][9]} Trenbolone acetate is an androgen ester and a short-lasting prodrug of trenbolone in the body.

Trenbolone acetate was discovered in 1963 and was introduced for veterinary use in the early 1970s.^[5][10][11] In addition to its veterinary use, trenbolone acetate is used to improve physique and performance, and is purchased from black market suppliers.^[5] The drug is a controlled substance in many countries and so non-veterinary use is generally illicit.^[5]

Uses[edit]

Veterinary uses[edit]

In the livestock industry, trenbolone acetate is more often called Finaplix. It was intentionally developed to promote androgen and gain muscle mass in cattle. Due to its properties, this allows livestock to grow as much muscle as possible before they are transported to a slaughterhouse.

Methyl cellulose and yellow dye are usually present in pellets given to livestock. A single dosage generally consists of 10 pellets, and a package of Finaplix usually consists of one cartridge, which contains 100 pellets (See Figure). This is usually given to the animal by means of a subcutaneous injection into the posterior location of the ear (See Figure) with the use of an implanter gun. Finaplix is consistently implanted until the animal is ready to be slaughtered. There is no withholding period. Due to the common practice of trenbolone acetate use in veterinary medicine, it is quite common to find traces of trenbolone metabolites in cattle worldwide.^[10][12]

Non-medical uses[edit]

Bodybuilding[edit]

Trenbolone acetate was never approved for use in humans and therefore guidelines for human consumption do not exist.^[5] However, athletes and bodybuilders have been using trenbolone acetate as a physique- and performance-enhancing drug for decades. There are a large number of benefits as a bodybuilder through using trenbolone acetate as an AAS. Unlike testosterone, trenbolone acetate does not cause any fluid retention while gaining muscle mass.^[10] This allows bodybuilders to appear leaner, and this is why it is more commonly used whilst preparing for competitive events. Trenbolone acetate does not convert into an estrogenic metabolite,^[10] and this results in a lack of estrogenic side effects.^[5] Trenbolone enanthate is also a very commonly used AAS and lasts much longer than trenbolone acetate with intramuscular injection.^[5]

Medical uses[edit]

Trenbolone acetate was never approved for use in humans and hence has no medical uses.^[5] However, as an AAS, it would be expected to be effective for indications in which other AAS are useful such as the treatment of conditions like androgen deficiency, wasting syndromes and muscle atrophy, and certain types of anemia.^[5][13]

Trenbolone was produced for human use as a human grade product, but only once. The product came in 1.5ml ampoules consisting of 76.2 mg of Trenbolone hexahydrobenzylcarbonate and made by Negma Pharmaceuticals of France.^{[citation needed]}

Side effects[edit]

Trenbolone acetate, like any other AAS, has many side effects.^[7][14][15] The strong androgenic nature of trenbolone acetate facilitates its tendency to produce virilization^[7] and this is why it is not recommended for women for physique- or performance-enhancing purposes.^[5] The side effects of trenbolone acetate are similar to other AAS; however, the negative side effects that are specifically facilitated by trenbolone acetate are as follows.

Androgenic[edit]

Trenbolone acetate has androgenic activity.^[16][17][18] Specific to the androgenic properties of trenbolone, common side effects of the AAS use include oily skin, acne, seborrhea, increased facial/body hair growth, and accelerated scalp hair loss.^[5][7][19] These side effects strongly rely on an individual’s genetics and may not always occur in every individual. Men susceptible to hair loss related illnesses, such as baldness have a higher chance of becoming permanently bald with the use of trenbolone acetate.^[7] In women, voice deepening, hirsutism, clitoral enlargement, and virilization in general may occur.^[5]

Hypogonadism[edit]

Trenbolone acetate contributes greatly to muscle mass and feed efficiency; however, administration of the AAS suppresses natural testosterone production; i.e., it has the potential to cause hypogonadism.^[5][14][19] This is a common effect of all AAS; the only difference is the variation in how much they suppress in comparison to others.

Cardiovascular[edit]

Administration of any AAS can lead to cardiovascular issues.^[20] Trenbolone acetate can have a negative and strong impact on cholesterol through suppressing both high-density lipoprotein (HDL) cholesterol and increasing low-density lipoprotein (LDL) cholesterol.^[21] When compared to oral AAS, trenbolone acetate has a stronger negative effect on cholesterol levels. This negative effect is much more severe with the use of injectable AAS, particularly trenbolone acetate.^[22]

«Tren cough»[edit]

The exact mechanisms underlying the cause of the tren cough are not known; however, trenbolone acetate’s androgenic effect activates a variety of lipid-like active compounds which are called prostaglandins.^[23] Many of these prostaglandins are inflammatory and vasoconstrictive. Prostaglandins are signalled through two varying pathways cyclooxygenase (COX) (Also known as: prostaglandin-endoperoxide synthase) and lipoxygenases (LOX) (also known as: EC 1.13.11.34, EC 1.13.11.33, etc.).^[24] The bradykinin peptide is well known to promote a cough reaction associated with ACE inhibitor medications prescribed for hypertension.^[25]

Estrogenic and progestogenic[edit]

No form of trenbolone, including trenbolone acetate, is estrogenic.^[5] Excess fluid retention is not possible with the administration of this AAS as a result of its not being estrogenic as opposed to testosterone.^[5] However, due to trenbolone’s potent progestogenic activity, gynecomastia, which is characterized by development and swelling of breast tissue,^[26] may still be possible.^{[citation needed]} Stimulation of estrogenic mechanisms are enforced by progestogenic activity^{[citation needed]} as trenbolone acetate and its compounds bind with high affinity to the progesterone receptor.^[10][18] It has been assumed that gynecomastia as a result of trenbolone use is due to a buildup of the hormone prolactin;^[26] however, a variety of studies conclude that it is the progestogenic activity of trenbolone promoting this and not prolactin.^{[citation needed]} Trenbolone also has a negative impact on blood pressure, but it does not appear to negatively affect most healthy adult men in this way.^{[citation needed]}

Pharmacology[edit]

Pharmacodynamics[edit]

Trenbolone acetate is a prodrug of trenbolone.^[2][5] Like other AAS, trenbolone is an agonist of the androgen receptor (AR) and hence has anabolic and androgenic activity as well as antigonadotropic activity.^{[5][2][8][17]} Trenbolone carries a rating for both anabolic potency and androgenic potency of 500, relative to a standard of nandrolone acetate (rating 100 for both).^[5][14] In addition to its anabolic and androgenic activity, trenbolone is an agonist of the progesterone receptor (PR), and in relation to this, has moderate to strong progestogenic activity.^[5][8][17] Conversely, trenbolone acetate is not a substrate for aromatase and hence lacks estrogenic activity.^[5][2][8] The compound also has weak glucocorticoid activity.^[8][9]

Similar to many other AAS, trenbolone acetate has the capability to produce insulin-like growth factor-1 (IGF-1).^[28][29] This naturally produced protein-based hormone affects every cell in the body of an organism and plays a large role in muscle recovery and rejuvenation. Extreme muscle growth and cell splitting compared is facilitated through trenbolone acetate administration when compared to other AAS.^[28] The facilitation of IGF-1 plays a significant role in the functions and properties of the central nervous system, pulmonary system, muscle tissue, ligaments, cartilage, and tendons.^[29]

Trenbolone acetate also has the ability to increase red blood cell count. With a larger amount of red blood cells, blood oxygenation is enhanced. This allows for enhanced muscular endurance and therefore promotes a faster rate of recovery. Trenbolone acetate is capable of inhibiting glucocorticoids such as cortisol.^{[citation needed]} The properties of glucocorticoid are the opposite of androgens as muscle tissue depletion and fat gain is promoted.^[30] Administration of trenbolone acetate aims at decreasing the production of glucocorticoid hormones. Trenbolone acetate’s contribution to feed efficiency, also known as nutrient efficiency is what makes it an attractive AAS used for agricultural purposes. Food is one of the most anabolic substances that any living organism can consume, and therefore with the administration of trenbolone acetate, every nutrient in the body becomes a lot more valuable.^[31] This facilitates an organism’s body that is exposed to the AAS to make better use of the nutrients already consumed.^[10][31]

Pharmacokinetics[edit]

The acetate ester of trenbolone acetate allows for slow release post injection. This ester gives trenbolone an activated elimination half-life of about 3 days.^[1]

Chemistry[edit]

Trenbolone acetate, or trenbolone 17β-acetate, is a synthetic estrane steroid and a derivative of nandrolone (19-nortestosterone).^[5][32][33] It is the C17β acetate ester of trenbolone, which itself is δ^9,11-19-nortestosterone (δ^9,11-19-NT) or estra-4,9,11-trien-17β-ol-3-one.^[5][32][33] Other trenbolone esters include trenbolone enanthate, trenbolone hexahydrobenzylcarbonate, and trenbolone undecanoate.^[5][32][33]

Structural properties of major anabolic steroid esters

Anabolic steroid	Structure	Ester	Relative mol. weight	Relative AAS contentb	Durationc
Position	Moiety	Type	Lengtha
Boldenone undecylenate		C17β	Undecylenic acid	Straight-chain fatty acid	11	1.58	0.63	Long
Drostanolone propionate		C17β	Propanoic acid	Straight-chain fatty acid	3	1.18	0.84	Short
Metenolone acetate		C17β	Ethanoic acid	Straight-chain fatty acid	2	1.14	0.88	Short
Metenolone enanthate		C17β	Heptanoic acid	Straight-chain fatty acid	7	1.37	0.73	Long
Nandrolone decanoate		C17β	Decanoic acid	Straight-chain fatty acid	10	1.56	0.64	Long
Nandrolone phenylpropionate		C17β	Phenylpropanoic acid	Aromatic fatty acid	– (~6–7)	1.48	0.67	Long
Trenbolone acetate		C17β	Ethanoic acid	Straight-chain fatty acid	2	1.16	0.87	Short
Trenbolone enanthated		C17β	Heptanoic acid	Straight-chain fatty acid	7	1.41	0.71	Long
Footnotes: a = Length of ester in carbon atoms for straight-chain fatty acids or approximate length of ester in carbon atoms for aromatic fatty acids. b = Relative androgen/anabolic steroid content by weight (i.e., relative androgenic/anabolic potency). c = Duration by intramuscular or subcutaneous injection in oil solution. d = Never marketed. Sources: See individual articles.

Structure–activity relationships[edit]

Trenbolone acetate is a modified form of nandrolone.^[16] The structure of trenbolone acetate is a 19-nor classification, which represents a structural change of the testosterone hormone. Trenbolone acetate lacks a carbon atom at the 19 position and carries a double bond at carbons 9 and 11. The position of these carbons slows its metabolism, which greatly increases its binding affinity to the AR, and inhibits it from undergoing aromatization into the corresponding estrogenic metabolite. Trenbolone acetate contains trenbolone modified with the addition of a carboxylic acid ester (acetic acid) at the 17β-hydroxyl group.^[10] This facilitates the slow release of the AAS from the area of injection.

History[edit]

Trenbolone acetate was first synthesized in 1963 and approved by the livestock industry as a growth promoter for beef cattle in the early 1970s.^[5][10][11] During this period of its first administration, trenbolone acetate was sold under the names Finajet and Finaject. The original manufacturer of trenbolone acetate discontinued during the late 1980s and administered the synthesis of subcutaneous pellets called Finaplix. These pellets aimed to increase muscle mass and lean tissue of cattle prior to slaughter to increase the profitability of livestock when measured in total pounds of meat sold.^[10]

The drug appears to have been an early development project of Roussel Uclaf, a French pharmaceutical company, and by the early 1970s, it was being sold as an injectable.^[18] There are a number of trenbolone esters but trenbolone acetate is the only one known to be produced in veterinary AAS manufacturers.

Trenbolone acetate became popular among bodybuilders and athletes during the early 1980s. During this period, the AAS was transported illegally from Europe in large quantities. Although trenbolone acetate was very popular for a short amount of time, the large amounts of supplies were discontinued in 1987.^[10] This decision was based upon the public concern of sports doping and its negative effects on athletes.^[5]

Society and culture[edit]

Generic names[edit]

Trenbolone acetate is the generic name of the drug and its USANTooltip United States Adopted Name, USPTooltip United States Pharmacopeia, and BANMTooltip British Approved Name.^{[3][4][32][33]}

Brand names[edit]

Trenbolone acetate is or has been sold alone for veterinary use under the brand names Component TH, Component TS, Finaject, Finajet, Finaplix-H, and Finaplix-S.^{[3][4][5][32][33]} It is or has also been sold in combination with estradiol or estradiol benzoate for veterinary use under the brand names Revalor and Synovex.^{[3][4][5][32][33]}

Distribution and regulation[edit]

Trenbolone acetate, specifically referred to as Finaplix in the livestock industry, is available to purchase in veterinary drug markets.^[5] A typical cartridge usually comes in the form of 20 mg pellets. It generally comes in the form of implant pellets containing 20 mg of trenbolone acetate each.^[32] Preparations containing trenbolone acetate remain rare since its decline in production after the 1980s. Using AAS for any other purpose, or without a doctor’s prescription, is illegal in most countries. Major sporting and bodybuilding organizations ban the use of controlled AAS, and the possession or sale of drugs can lead to arrest and conviction of drug-trafficking in many countries, including the United States and Australia. However, in the United Kingdom, owning AAS for personal use as a bodybuilding supplement is not illegal, but selling the AAS without a valid medical license or reason is still against the law.^[34]

Doping in sports[edit]

Regardless of their legality, AAS are still banned by most sporting leagues in the country, who routinely conduct drug tests to find the users of any AAS. There are known cases of doping in sports with trenbolone acetate by professional athletes.

References[edit]

Further reading[edit]

External links[edit]

В каталоге интернет-магазина Брутал Маркет мы представили вашему вниманию ряд анаболиков, в частности Тренболон ацетат, применяя которые, вы всегда будете чувствовать себя превосходно, и ничто не помешает вам быть в безупречной форме.

Тренболон ацетат — это препарат группы стероидов, является мощным анаболическим средством. Стероид предназначен для внутримышечного введения спортсменам, с целью сжигания жировых отложений и ускорения роста мышечной массы, он имеет значимое отличие от аналогов: высокую скорость полураспада.

Способ применения

Для достижения максимального эффекта, без проявления негативной реакции организма, специалисты советуют вводить анаболическое средство данного типа опытным спортсменам. Период введения составляет 50 мл через день, либо 300 мл еженедельно. Начинать прием следует с минимальной дозировки, и постепенно ее увеличивать: такой способ применения позволит избежать побочных проявлений, поскольку организм будет адаптироваться постепенно, а риск негативной реакции будет максимально снижен.

Важно! Препарат необходимо вводить при помощи шприца в мышцы, строго соблюдая указанную дозировку. Новичкам следует делать инъекции, начиная с минимальной дозировки, и постепенно ее увеличивать. Если прием препарата предположительно будет составлять более 5 недель, то начиная со второй недели дозировку можно увеличивать на 100-500Мг.

Инструкция и рекомендации по применению

В связи с сильным действием препарата, Тренболон ацетат от SP labs специалисты рекомендуют принимать под наблюдением профессионалов, либо только опытным спортсменам, и не советуют принимать женщинам. Основными преимуществами средства являются особенности его действия на организм человека:

• стимулирует рост мышечной массы человека;
• сжигает жировые отложения, которые накапливались годами;
• способствует повышению либидо;
• повышает силовые показатели;
• снижает выработку кортизола, тем самым нормализует нервное состояние и артериальное давление при повышенных физических нагрузках.

Так, спортсмены отмечают исключительно положительные стороны препарата, при условии строгого соблюдения рекомендаций относительно его приема.

Как заказать Тренболон ацетат

Чтобы приобрести Тренболон ацетат в Брутал Маркет, вам потребуется осуществить несколько простых действий

• перейти на официальный сайт нашего магазина;
• добавить средство в корзину, выбрав необходимую дозировку;
• выбрать способ доставки;
• указать собственные данные и адрес.

Оплата осуществляется при получении товара после его предварительной проверки получателем.

СТАЙЛАБ предлагает тест-системы для определения тренболона в мясе, печени, желчи, плазме крови, моче и фекалиях методом ИФА, а также стандартные растворы и образцы  тренболона.

Тренболон, впервые синтезированный в 1963 году, является синтетическим стероидом, производным нандролона. Химическая структура тренболона обуславливает выраженные анаболический и андрогенный эффект. Обычно в медицине и сельском хозяйстве используют ацетат, энантат или циклогексилметилкарбонат тренболона, что позволяет увеличить время его действия. В организме из этих веществ образуется тренболон.

Изначально тренболон применяли в животноводстве в качестве стимулятора роста животных, однако в 1980-х годах его начали использовать спортсмены, оценившие влияние этого вещества на мышечную массу и силу. Отсутствие побочных эффектов, характерных для многих других синтетических анаболиков: отеков, вызванных задержкой в организме воды и увеличения жировой массы сделало препараты тренболона популярным как среди профессиональных бодибилдеров, так и среди спортсменов-любителей.

Сродство тренболона к рецепторам к прогестерону обуславливает его эстрогенные эффекты, выражающиеся в гинекомастии. Кроме того, он обладает и андрогенным действием: употребление тренболона может приводить к появлению акне, облысению у мужчин, росту волос  по мужскому типу и изменению голоса у женщин и другим характерным нарушениям. В высоких дозах тренболон иногда вызывает поражения печени, однако в низких он не проявляет гепатотоксичности. Как и другие анаболические андрогенные стероиды, тренболон способствует развитию атеросклероза и увеличивает риск возникновения сердечно-сосудистых заболеваний. Он также снижает выработку эндогенного тестостерона у мужчин. Исследования, проведенные на культурах клеток человека показали, что тренболон проявляет генотоксичность и способен вызывать повреждения хромосом.

Тренболон входит в Список запрещенных в спорте препаратов и методов ВАДА. Несмотря на это, его иногда используют в качестве допинга. Кроме того, некоторые производители применяют тренболон при выращивании сельскохозяйственных животных. Такая практика запрещена в России и странах Евросоюза. Это связано и с опасностью для потребителя, и с влиянием тренболона на экосистемы. Основные метаболиты тренболона – 17β-тренболон и его изомер 17α-тренболон. Последний частично метаболизируется с образованием трендиона. Время полураспада этих трех веществ в воде составляет около 35 суток; в донных осадках – около 53 суток. При этом метаболиты тренболона воздействуют на рыб и водных животных.

Определение тренболона методом газовой хроматографии осложнено его разрушением в ходе анализа. В настоящее время для анализа тренболона все чаще используют метод ИФА (иммуноферментного анализа). Он прост в постановке, не требует дорогостоящего оборудования и позволяет за короткое время проверить большое количество проб и получить точные результаты исследования. Это позволяет использовать тест-системы для ИФА для скрининга проб при определении тренболона.

Литература

1. Schänzer W. Metabolism of anabolic androgenic steroids. Clin Chem. 1996 Jul;42(7):1001-20.
2. William Llewellyn. Anabolics. Molecular Nutrition Llc., 2011
3. Beg, Tanveer; Siddique, Yasir Hasan; Afzal, Mohammad (2007). Chromosomal Damage Induced by Androgenic Anabolic Steroids, Stanozolol and Trenbolone, in Human Lymphocytes. Advances in Environmental Biology 1 (1): 39–43.
4. Robinson JA, Ma Q, Staveley JP, Smolenski WJ, Ericson J.Degradation and transformation of 17α-trenbolone in aerobic water-sediment systems. Environ Toxicol Chem. 2016 Jan 23.
5. Tomkins P, Saaristo M, Allinson M, Wong BB. Exposure to an agricultural contaminant, 17β-trenbolone, impairs female mate choice in a freshwater fish. Aquat Toxicol. 2016 Jan;170:365-70.
6. Massart S, Redivo B, Flamion E, Mandiki SN, Falisse E, Milla S, Kestemont P. The trenbolone acetate affects the immune system in rainbow trout, Oncorhynchus mykiss. Aquat Toxicol. 2015 Jun;163:109-20.