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₵95.00
Duo-Cotecxin 40/320 Tablet
Duo-Cotecxin 40/320 Tablet is indicated for the treatment of uncomplicated Plasmodium falciparum malaria in adults, adolescents, children and infants 6 months and over and weighing 5 kg or more.
Consideration should be given to official guidance on the appropriate use of antimalarial medicinal products.
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Duo-Cotecxin®
Dihydroartemisinin 40mg and Piperaquine phosphate 320mg anhydrous basis) tablets (called Duo-Cotecxin in this leaflet) contains two active components called
· dihydroartemisinin and
· piperaquine phosphate,
makes this antimalarial drug belong to the class called ACTs (Artemisinin Combination Therapies). This medicine is used to treat falciparum malaria and vivax malaria, particularly in case of resistance to other antimalarials.
Duo-Cotecxin is highly beneficial as it provides a longer post treatment protection from malaria. This is as a result of the Piperaquine Phosphate lasting in the blood plasma for 9 to 20 days and in some cases up to 30 days.
Usage
· Swallow the tablets with a little water, after a meal.
· For young children, tablets can be crushed and given with some water.
Medicines are given only once a day, a complete treatment is for 3 days.
For more information, visit us on our website
Description and Composition of Duo-Cotecxin
Duo-Cotecxin is a drug used in the treatment of uncomplicated malaria. It that contains Dihydroartemisinin and Piperaquine as its active pharmaceutical ingredients. It also contains inactive ingredients called excipients in sufficient quantities. Duo-Cotecxin is available in different dosage forms including tablets, and powder for Suspension. Each film coated tablet contains:
- Single strength: Dihydroartemisinin 40 mg + Piperaquine 320 mg
- Tetra Strength: Dihydroartemisinin 120 mg + Piperaquine 960 mg.
Pharmacodynamics of Duo-Cotecxin
Dihydroartemisinin mainly interferes with the membrane structures of trophozoites (erythrocytic asexual forms), i.e, whorled food vacuole membrane, distended mitochondria, swollen nuclear membranes, dissociation of ribosomes from endoplasmic reticulum leading to cytoplasmic vacuolization and autophagocytosis. In addition, biochemical depression of protein synthesis and nucleic acid synthesis are exhibited.
Experimental results show that Piperaquine Phosphate interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites. It has no marked effect on the ring forms, immature or mature schizonts and the male or female gametocytes.
Pharmacokinetics of Duo-Cotecxin
Upon oral administration Dihydroartemisin is rapidly absorbed and maximum blood concentration attained 1 hour afterwards, with a half-life of about 4 hours. It is widely distributed in the liver, kidneys and bile. Approximately 80% is excreted through the urine and feces within 24 hrs after administration. It is metabolized to two inactive metabolites, deoxydihydroartemisinin and dihydroxydihydroartemisinin.
Upon oral administration, about 80-90% is absorbed within 24 hrs. It is widely distributed in the body mainly in the liver, kidneys, lungs and spleen. About 25% of the total dose is partitioned in the liver within 8 hrs of intake. Elimination is very slow with the half life of about 9.4 days. It is excreted through bile by hepatoenteral circulation.
Uses and Indications of Duo-Cotecxin
Duo-Cotecxin tablets are indicated for the treatment of uncomplicated Plasmodium falciparum malaria.
Administration and Dosage of Duo-Cotecxin
Oral administration: Duo-Cotecxin Tablets and Suspension should be given daily for 3 days.
Patient should follow doctor’s instruction. The recommended dosages according to body Weight are as follows:
Tablets
- 5 to < 8 kg: ½ tablet once daily for 3 days
- 8 to < 11 kg: 1½ tab of 20mg/160mg
- 11 to <17 kg: 1 tablet daily for 3 days
- 17 to < 25 kg: 1.5 tablets daily for 3 days
- 25 to < 36 kg: 2 tablets daily for 3 days
- 36 to < 60 kg: 3 tablets daily for 3 days
- 60 to < 80 kg: 4 tablets daily for 3 days
- >80 kg: 5 tablets daily for 3 days
Oral Suspension
DHA-PQP 80 mg + 640 mg/80 mL Oral suspension
- 5 to < 8 kg: 20ml once daily for 3 days
- 8 to < 11 kg: 30ml once daily for 3 days
- 11 to < 17 kg: 40ml once daily for 3 days
- 17 to < 25 kg: 60ml once daily for 3 days
- 25 to < 36 kg: 80ml once daily for 3 days
Note:
- One tablet in the above dosage guideline represents Duo-Cotecxin 40mg/320mg. That’s the single strength.
Warning and Precautions
Caution should be taken while administering drug to patients with hepatic, kidney impairment. Do not exceed the stated dosage.
Duo-Cotecxin Use in Pregnancy and Lactation
There are insufficient data on the use of dihydroartemisinin and piperaquine in pregnant women. Based on animal data, Duo-Cotecxin is suspected to cause serious birth defects when administered during the first trimester of pregnancy. Reproductive studies with artemisinin derivatives have demonstrated teratogenic potential with an increased risk during early gestation Duo-Cotecxin should not be used during pregnancy in situations where other suitable and effective anti-malarials are available..
Animal data suggest excretion of piperaquine into breast milk but no data are available in humans. Women taking Duo-Cotecxin should not breast-feed during their treatment.
Drugs Interactions with Duo-Cotecxin
Caution should be taken while administering Duo-Cotecxin tablets with drugs such as inhibitors of CYP3A4, CYP2C19. rifampicin, carbamazepine, phenytoin and phenobarbital.
Nausea or vomiting may occur occasionally with incidence of less than 6% No noticeable side effect of Dihydroartemisinin is reported. The Dihydroartemisinin would, for certain individuals, bring effects of greater or lesser severity: for example, a reversible reduction in reticulocyte counts.
Possible side-effect of Piperaquine Phosphate include mild dizziness, vertigo, headache, nausea, vomiting and abdominal discomfort. Reversible leucopenia was infrequently reported; dyspnea and palpitations were also reported but not further specified.
Overdose of Duo-Cotecxin
In cases of suspected overdose, symptomatic and supportive therapy should be given as appropriate, including ECG monitoring because of the possibility of QTc interval prolongation.
How to Store Duo-Cotecxin
Store in a dry place, below 30°C. Protect from light. Keep out of reach of children.
References
- MSF Medical Guidelines
- Hindawi Journal
- P-Alaxin Drug Information
- Overview
- Uses
- Side-effects
- Precautions
- Interactions
- Contraindications
Overview
Duo cotecxin Tablet is used for Malaria and other conditions. Duo cotecxin Tablet may also be used for purposes not listed in this medication guide.
Duo cotecxin Tablet works by incorporating the parasite killing effect; possessing the antimalarial activity;
Detailed information related to Duo cotecxin Tablet’s uses, composition, dosage, side effects and reviews is listed below.
Uses
Side-effects
The following is a list of possible side-effects that may occur from all constituting ingredients of Duo cotecxin Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
- Nausea
- Anorexia
- Abdominal pain
- Diarrhea
- Dizziness
- Itching
- Duo cotecxin Tablet may also cause side-effects not listed here.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
Precautions
Before using Duo cotecxin Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
- second and third trimesters of pregnancy
Interactions with Duo cotecxin Tablet
If you use other drugs or over the counter products at the same time, the effects of Duo cotecxin Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Duo cotecxin Tablet may interact with the following drugs and products:
- Mefloquine
Composition and Active Ingredients
Packages and Strengths
Please consult your physician or pharmacist or product package for this information.
Frequently asked Questions
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Is Duo cotecxin Tablet safe to use when pregnant?
- Dihydroartemisinin: Please consult with your doctor for case-specific recommendations.
- Piperaquine Phosphate: Please consult with your doctor for case-specific recommendations.
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Is Duo cotecxin Tablet safe while breastfeeding?
- Dihydroartemisinin: Please discuss the risks and benefits with your doctor.
- Piperaquine Phosphate: Please discuss the risks and benefits with your doctor.
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How long do I need to use Duo cotecxin Tablet before I see improvement of my conditions?
TabletWise.com website users have reported 3 days and > 3 months as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Duo cotecxin Tablet. Click here and view survey results to find out what other patients report as time for effectiveness for Duo cotecxin Tablet.
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At what frequency do I need to use Duo cotecxin Tablet?
TabletWise.com website users have reported once a day and other as the most common frequency of using Duo cotecxin Tablet. Please follow your doctor’s advice on how often you need to Duo cotecxin Tablet. Click here and view survey results to find out what other patients report as frequency of using Duo cotecxin Tablet.
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Should I use Duo cotecxin Tablet empty stomach, before food or after food?
TabletWise.com website users have most commonly reported using Duo cotecxin Tablet after food. However, this may not be reflective of how you should use this medicine. Please follow your doctor’s advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Duo cotecxin Tablet.
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Is it safe to drive or operate heavy machinery when using this product?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Duo cotecxin Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Duo cotecxin Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.
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Is this medicine or product addictive or habit forming?
Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.
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Can i stop using this product immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.
Other important Information on Duo cotecxin Tablet
Missing a dose
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
Overdosage of Duo cotecxin Tablet
- Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Duo cotecxin Tablet, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
- Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
- Please consult your physician or pharmacist or product package for more information.
Storage of Duo cotecxin Tablet
- Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
- Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Duo cotecxin Tablet.
Expired Duo cotecxin Tablet
- Taking a single dose of expired Duo cotecxin Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
Dosage Information
Please consult your physician or pharmacist or refer to the product package.
Cite this page
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APA Style Citation
- Duo cotecxin Tablet — Product — TabletWise.com. (n.d.). Retrieved October 19, 2023, from https://www.tabletwise.com/nigeria/duo-cotecxin-tablet
MLA Style Citation
- «Duo cotecxin Tablet — Product — TabletWise.com» Tabletwise.com. N.p., n.d. Web. 19 Oct. 2023.
Chicago Style Citation
- «Duo cotecxin Tablet — Product — TabletWise.com» Tabletwise. Accessed October 19, 2023. https://www.tabletwise.com/nigeria/duo-cotecxin-tablet.
Last updated date
This page was last updated on 9/27/2020.
This page provides information for Duo cotecxin Tablet Product in English.
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Malaria
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Duo-Cotecxin
₵13.89
Duo-Cotecxin contains Dihydroartemisin 40mg/ Piperaquine 320 mg and it treats uncomplicated Malaria. The dosage is in the form of tablets.
Duo-Cotecxin quantity
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Description
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Description
Duo-Cotecxin is an artemisinin based combination therapy (ACT). It contains Dihydroartemisinin 40mg and Piperaquine phosphate 320mg. Duo Cotecxin treats uncomplicated malaria.
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