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Name of the medicinal product
Depon Maximum
Therapeutic indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, Depon Maximum or Depon Maximum is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of Depon Maximum. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Depon Maximum® (Depon Maximum) injection is indicated for
- the management of mild to moderate pain
- the management of moderate to severe pain with adjunctive opioid analgesics
- the reduction of fever.
Depon Maximum injection is used together with other medicines (eg, narcotic pain relievers) to relieve moderate to severe pain.
Depon Maximum is used to relieve mild to moderate pain and reduce fever in patients. It does not become habit-forming when taken for a long time. Depon Maximum may cause unwanted effects when taken in large doses, including liver damage.
Depon Maximum is available only with your doctor’s prescription.
Dosage (Posology) and method of administration
General Dosing Information
Depon Maximum may be given as a single or repeated dose for the treatment of acute pain or fever. No dose adjustment is required when converting between oral Depon Maximum and Depon Maximum dosing in adults and adolescents who weigh 50 kg and above. Calculated maximum daily dose of Depon Maximum is based on all routes of administration (i.e., intravenous, oral, and rectal) and all products containing Depon Maximum. Exceeding the maximum mg/kg daily dose of Depon Maximum as described in Tables 1 and 2 may result in hepatic injury, including the risk of liver failure and death. To avoid the risk of overdose, ensure that the total amount of Depon Maximum from all routes and from all credits does not exceed the maximum recommended dose.
Recommended
Dosage: Adults and Adolescents
Adults and adolescents weighing 50 kg and over: the recommended dosage of Depon Maximum is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Depon Maximum of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Depon Maximum of 4000 mg per day (includes all routes of administration and all Depon Maximum-containing products including combination products).
Adults and adolescents weighing under 50 kg: the recommended dosage of Depon Maximum is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Depon Maximum of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Depon Maximum of 75 mg/kg per day (includes all routes of administration and all Depon Maximum-containing products including combination products).
Table 1: Dosing for Adults and Adolescents
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Depon Maximum (by all routes) |
| Adults and adolescents (13 years and older) weighing ≥ 50 kg | 650 mg | 1000 mg | 1000 mg | 4000 mg in 24 hours |
| Adults and adolescents (13 years and older) weighing < 50 kg | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3750 mg) |
Recommended
Dosage: Children
Children 2 to 12 years of age: the recommended dosage of Depon Maximum is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Depon Maximum of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Depon Maximum of 75 mg/kg per day.
Table 2: Dosing for Children
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Depon Maximum (by all routes) |
| Children 2 to 12 years of age | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3750 mg) |
Instructions For
Intravenous Administration
For adult and adolescent patients weighing ≥ 50 kg requiring 1000 mg doses of Depon Maximum, administer the dose by inserting a vented intravenous set through the septum of the 100 mL vial. Depon Maximum may be administered without further dilution. Examine the vial contents before dose preparation or administering. DO NOT USE if particulate matter or discoloration is observed. Administer the contents of the vial intravenously over 15-minutes. Use aseptic technique when preparing Depon Maximum for intravenous infusion. Do not add other medications to the Depon Maximum vial or infusion device.
For doses less than 1000 mg, the appropriate dose must be withdrawn from the vial and placed into a separate container prior to administration. Using aseptic technique, withdraw the appropriate dose (650 mg or weight-based) from an intact sealed Depon Maximum vial and place the measured dose in a separate empty, sterile container (e.g. glass bottle, plastic intravenous container, or syringe) for intravenous infusion to avoid the inadvertent delivery and administration of the total volume of the commercially available container. The entire 100 mL vial of Depon Maximum is not intended for use in patients weighing less than 50 kg. Depon Maximum is a single-use vial and the unused portion must be discarded.
Place small volume pediatric doses up to 60 mL in volume in a syringe and administer over 15 minutes using a syringe pump.
Monitor the end of the infusion in order to prevent the possibility of an air embolism, especially in cases where the Depon Maximum infusion is the primary infusion.
Once the vacuum seal of the glass vial has been penetrated, or the contents transferred to another container, administer the dose of Depon Maximum within 6 hours.
Do not add other medications to the Depon Maximum solution. Diazepam and chlorpromazine hydrochloride are physically incompatible with Depon Maximum, therefore do not administer simultaneously.
How supplied
Dosage Forms And Strengths
Depon Maximum is a sterile, clear, colorless, non pyrogenic, preservative free, isotonic formulation of Depon Maximum intended for intravenous infusion. Each 100 mL glass vial contains 1000 mg Depon Maximum (10 mg/mL).
Storage And Handling
NDC 43825-102-01 — Depon Maximum® (Depon Maximum) Injection is supplied in a 100 mL glass vial containing 1000 mg Depon Maximum (10 mg/mL) in cartons of 24 vials.
Depon Maximum should be stored at 20°C to 25°C (68°F to 77°F).
For single use only. The product should be used within 6 hours after opening. Do not refrigerate or freeze.
Manufactured for: Mallinckrodt Hospital Products Inc., Hazelwood, MO 63042 USA. Revised: Dec 2014
Contraindications
See also:
What is the most important information I should know about Depon Maximum?
There are many brands and forms of Depon Maximum available and not all brands are listed on this leaflet.
Do not take more of this medication than is recommended. An overdose of Depon Maximum can damage your liver or cause death.
Know the amount of Depon Maximum in the specific product you are taking.
Do not take this medication without a doctor’s advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take Depon Maximum.
Avoid drinking alcohol. It may increase your risk of liver damage while taking Depon Maximum.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have liver disease or a history of alcoholism.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Depon Maximum (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much Depon Maximum which can lead to a fatal overdose. Check the label to see if a medicine contains Acetaminophen or APAP.
Special warnings and precautions for use
Use Depon Maximum injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Depon Maximum injection is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Depon Maximum injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Depon Maximum injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not mix other medicines (especially chlorpromazine or diazepam) in the same container or IV line as Depon Maximum injection. Contact your health care provider if you have any questions about how to give Depon Maximum injection with other medicines.
- Do not use Depon Maximum injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Use Depon Maximum injection within 6 hours after opening.
- If you miss a dose of Depon Maximum injection and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Depon Maximum injection.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
How to use Depon Maximum Extra Strength
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
There are many brands and forms of Depon Maximum available. Read the dosing instructions carefully for each product because the amount of Depon Maximum may be different between products. Do not take more Depon Maximum than recommended.
If you are giving Depon Maximum to a child, be sure you use a product that is meant for children. Use your child’s weight to find the right dose on the product package. If you don’t know your child’s weight, you can use their age.
For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.
For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.
Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.
Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.
Interaction with other medicinal products and other forms of interaction
See also:
What other drugs will affect Depon Maximum?
Depon Maximum is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Depon Maximum [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Depon Maximum and may decrease the action of Depon Maximum. Doses of Depon Maximum greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Depon Maximum to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Depon Maximum by decreasing its absorption into the body from the intestine. Therefore, Depon Maximum should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Depon Maximum doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Depon Maximum should be avoided during warfarin therapy
Undesirable effects
See also:
What are the possible side effects of Depon Maximum?
Applies to Depon Maximum: capsule, capsule liquid filled, elixir, liquid, powder, powder for solution, solution, suppository, suspension, syrup, tablet, tablet chewable, tablet disintegrating, tablet effervescent, tablet extended release
Other dosage forms:
- intravenous solution
Along with its needed effects, Depon Maximum (the active ingredient contained in Depon Maximum) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking Depon Maximum:
Rare
- Bloody or black, tarry stools
- bloody or cloudy urine
- fever with or without chills (not present before treatment and not caused by the condition being treated)
- pain in the lower back and/or side (severe and/or sharp)
- pinpoint red spots on the skin
- skin rash, hives, or itching
- sore throat (not present before treatment and not caused by the condition being treated)
- sores, ulcers, or white spots on the lips or in the mouth
- sudden decrease in the amount of urine
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking Depon Maximum:
Symptoms of overdose
- Diarrhea
- increased sweating
- loss of appetite
- nausea or vomiting
- stomach cramps or pain
- swelling, pain, or tenderness in the upper abdomen or stomach area
Qualitative and quantitative composition
Depon Maximum (with the Optizorb formulation) also contains the following excipients: Pregelatinized maize starch, calcium carbonate, alginic acid, crospovidone, povidone, magnesium stearate, colloidal anhydrous silica, parahydroxybenzoates (sodium methyl, ethyl and propyl), OPADRY YS-1-7003 white, carnauba wax, purified water.
It contains no sugar, lactose or gluten.
References:
- https://www.drugs.com/mtm/salicylic-acid-topical.html
- https://pubmed.ncbi.nlm.nih.gov/?term=depon-maximum
Available in countries
Find in a country:
Home – Depon Maximum
Depon Maximum Drug Information [ Bristol-Myers Squibb ]
Table of content
Depon Maximum category:
- Human
- Analgetics Acetaminophen Salicylates Codeine
- Miscellaneous Analgesics and Antipyretics
Active ingredients:
- Acetaminophen
Depon Maximum companies and manufacturers:
-
Bristol-Myers Squibb
General Information
Depon Maximum forms, composition and dosages:
- N / A
Indications, usages and classification codes:
- N02BE01 — Acetaminophen (Paracetamol)
There is an additional general information about this medication active ingredient paracetamol (acetaminophen):
Pharmacological action
Analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Depon Maximum prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Paracetamol dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission — up to 4 times / Maximum duration of treatment — 5-7 days.
Maximum dose: single — 1 g, daily — 4 g.
Single dose for oral administration for children aged 6-12 years — 250-500 mg, 1-5 years — 120-250 mg, from 3 months to 1 year — 60-120 mg, up to 3 months — 10 mg / kg. Single dose rectal in children aged 6-12 years — 250-500 mg, 1-5 years — 125-250 mg.
Multiplicity — 4 at intervals of not less than 4 h. The maximum duration of treatment — 3 days.
Maximum dose: 4 single dose per day.
Depon Maximum Side Effects
Digestive system: rarely — dyspepsia; long-term use at high doses — hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia.
Hemopoietic system: rarely — thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis.
Allergic reactions: rarely — skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to paracetamol, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Paracetamol crosses the placental barrier. So far, no observed adverse effects of paracetamol on the fetus in humans.
Paracetamol is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of paracetamol during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of paracetamol.
Special Instructions
With caution used in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of paracetamol is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Depon Maximum Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of paracetamol.
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of paracetamol.
With the simultaneous use of oral contraceptives accelerated excretion of paracetamol from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of paracetamol.
When applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with paracetamol. A case of severe toxic liver injury.
Described cases of toxic effects of paracetamol, while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of paracetamol, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of paracetamol and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of paracetamol may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of paracetamol and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of paracetamol, with rifampicin, sulfinpyrazone — may increase clearance of paracetamol due to increasing its metabolism in the liver.
At simultaneous application with ethinylestradiol increases absorption of paracetamol from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce — rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Depon Maximum in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Storage Conditions
In a dry, protected from light place, temperature 15-25 °C.
Expiration date for paracetamol: 3 years.
PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
- Depon Maximum analogs
- Depon Maximum similar
Состав:
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Топ 20 лекарств с такими-же компонентами:
Название медикамента
Описание Название медикамента Depon Maximumявляется автоматическим переводом с языка оригинала.
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Терапевтические показания
Описание Терапевтические показания Depon Maximumявляется автоматическим переводом с языка оригинала.
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Способ применения и дозы
Описание Способ применения и дозы Depon Maximumявляется автоматическим переводом с языка оригинала.
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Противопоказания
Описание Противопоказания Depon Maximumявляется автоматическим переводом с языка оригинала.
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Особые предупреждения и меры предосторожности
Описание Особые предупреждения и меры предосторожности Depon Maximumявляется автоматическим переводом с языка оригинала.
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There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
Взаимодействие с другими лекарствами
Описание Взаимодействие с другими лекарствами Depon Maximumявляется автоматическим переводом с языка оригинала.
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Обязательно изучайте оригинальную инструкцию лекарства из упаковки.
В данном описании могут присутствовать многочисленные ошибки из-за автоматического перевода!
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Побочные эффекты
Описание Побочные эффекты Depon Maximumявляется автоматическим переводом с языка оригинала.
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Передозировка
Описание Передозировка Depon Maximumявляется автоматическим переводом с языка оригинала.
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Состав
Описание Состав Depon Maximumявляется автоматическим переводом с языка оригинала.
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Обязательно изучайте оригинальную инструкцию лекарства из упаковки.
В данном описании могут присутствовать многочисленные ошибки из-за автоматического перевода!
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Источники:
- https://www.drugs.com/mtm/salicylic-acid-topical.html
- https://pubmed.ncbi.nlm.nih.gov/?term=depon-maximum
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Страна: Греция
Язык: греческий
Источник: Εθνικός Οργανισμός Φαρμάκων
Купи это сейчас
Активный ингредиент:
PARACETAMOL
Доступна с:
UPSA SAS, FRANCE 3 Rue Joseph Monier, 92500 Rueil-Malmaison
код АТС:
N02BE01
ИНН (Международная Имя):
PARACETAMOL
дозировка:
1000MG/TAB
Фармацевтическая форма:
F.C.TAB (ΕΠΙΚΑΛΥΜΜΕΝΟ ΜΕ ΛΕΠΤΟ ΥΜΕΝΙΟ ΔΙΣΚΙΟ)
состав:
PARACETAMOL 1.000MG
Администрация маршрут:
ΑΠΟ ΤΟΥ ΣΤΟΜΑΤΟΣ
Производитель:
ΒΙΑΝΕΞ Α.Ε. ΑΝΩΝΥΜΟΣ ΕΜΠΟΡΟΒΙΟΜΗΧΑΝΙΚΗ-ΤΟΥΡΙΣΤΙΚΗ-ΞΕΝΟΔΟΧΕΙΑΚΗ ΚΑΙ ΝΑΥΤΙΛΙΑΚΗ ΑΝΩΝΥΜΟΣ ΕΤΑΙΡΕΙΑ Δ.Τ. ΒΙΑΝΕΞ Α.Ε. Οδός Τατοϊου,, 18ο χλμ. Εθνικής Οδού Αθηνών-Λαμίας, 210.8009111-119
Терапевтические области:
PARACETAMOL
Обзор продуктов:
Αρ. άδειας: 79893/18-07-2022; Διαδικασία: Εθνική; Συσκευασίες: 2800232813014 BT X 1 BLISTER (ALU/PVC) X 8 TABS 8ΤΕ Εγκεκριμένο ΦΑΡΜΑΚΕIOY Εκτός τιμοκαταλόγου
Статус Авторизация:
Εγκεκριμένο
тонкая брошюра
1
ΦΥΛΛΟ ΟΔΗΓΙΩΝ ΧΡΗΣΗΣ
2
ΦΎΛΛΟ ΟΔΗΓΙΏΝ ΧΡΉΣΗΣ: ΠΛΗΡΟΦΟΡΊΕΣ ΓΙΑ
ΤΟΝ ΧΡΉΣΤΗ
DEPON 500 MG ΔΙΣΚΊΑ
DEPON 500 MG ΕΠΙΚΑΛΥΜΜΈΝΑ ΜΕ ΛΕΠΤΌ ΥΜΈΝΙΟ
ΔΙΣΚΊΑ
DEPON MAXIMUM 1000 MG ΕΠΙΚΑΛΥΜΜΈΝΑ ΜΕ ΛΕΠΤΌ
ΥΜΈΝΙΟ ΔΙΣΚΊΑ
DEPON 500 MG ΑΝΑΒΡΆΖΟΝΤΑ ΔΙΣΚΊΑ
DEPON 200 MG ΥΠΌΘΕΤΑ
DEPON 600 MG ΥΠΌΘΕΤΑ
DEPON 120 MG/5 ML ΣΙΡΌΠΙ
DEPON MAXIMUM 1 G ΑΝΑΒΡΆΖΟΝΤΑ ΔΙΣΚΊΑ
DEPON ODIS 500 MG ΔΙΑΣΠΕΙΡΌΜΕΝΑ ΣΤΟ ΣΤΌΜΑ
ΔΙΣΚΊΑ
παρακεταμόλη
ΔΙΑΒΆΣΤΕ ΠΡΟΣΕΚΤΙΚΆ ΟΛΌΚΛΗΡΟ ΤΟ ΦΎΛΛΟ
ΟΔΗΓΙΏΝ ΧΡΉΣΗΣ ΠΡΙΝ ΑΡΧΊΣΕΤΕ ΝΑ
ΠΑΊΡΝΕΤΕ ΑΥΤΌ ΤΟ
ΦΆΡΜΑΚΟ, ΔΙΌΤΙ ΠΕΡΙΛΑΜΒΆΝΕΙ
ΣΗΜΑΝΤΙΚΈΣ ΠΛΗΡΟΦΟΡΊΕΣ ΓΙΑ ΣΑΣ.
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γιατρού ή του φαρμακοποιού σας.
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ενέργεια, ενημερώστε τον γιατρό ή τον
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σας. Αυτό ισχύει και για κάθε πιθανή
ανεπιθύμητη ενέργεια που δεν
αναφέρεται στο παρόν
φύλλο οδηγιών χρήσης. Βλέπε παράγραφο
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Характеристики продукта
1
ΠΕΡΙΛΗΨΗ ΤΩΝ ΧΑΡΑΚΤΗΡΙΣΤΙΚΩΝ ΤΟΥ
ΠΡΟΪΟΝΤΟΣ
2
1.
ΟΝΟΜΑΣΙΑ ΤΟΥ ΦΑΡΜΑΚΕΥΤΙΚΟΥ ΠΡΟΪΟΝΤΟΣ
DEPON 500 mg δισκία
DEPON 500 mg επικαλυμμένο με λεπτό υμένιο
δισκία
DEPON MAXIMUM 1000 mg επικαλυμμένα με λεπτό
υμένιο δισκία
DEPON 500 mg αναβράζοντα δισκία
DEPON 200 mg υπόθετα
DEPON 600 mg υπόθετα
DEPON 120 mg/5 ml σιρόπι
DEPON MAXIMUM 1 g αναβράζοντα δισκία
DEPON ODIS 500 mg διασπειρόμενα στο στόμα
δισκία
2.
ΠΟΙΟΤΙΚΗ ΚΑΙ ΠΟΣΟΤΙΚΗ ΣΥΝΘΕΣΗ
DEPON 500 mg δισκία: κάθε δισκίο περιέχει 500
mg παρακεταμόλης.
DEPON 500 mg επικαλυμμένα με λεπτό υμένιο
δισκία: κάθε επικαλυμμένο με λεπτό
υμένιο δισκίο
περιέχει 500 mg παρακεταμόλης.
DEPON MAXIMUM 1000 mg επικαλυμμένα με λεπτό
υμένιο δισκία: κάθε επικαλυμμένο με
λεπτό
υμένιο δισκίο περιέχει 1000 mg
παρακεταμόλης
DEPON 500 mg αναβράζοντα δισκία: κάθε
αναβράζον δισκίο περιέχει 500 mg
παρακεταμόλης.
DEPON MAXIMUM 1 g αναβράζοντα δισκία: κάθε
αναβράζον δισκίο περιέχει 1 g
παρακεταμόλης.
DEPON ODIS 500 mg διασπειρόμενα στο στόμα
δισκία: κάθε διασπειρόμενο στο στόμα
δισκίο περιέχει
540,50 mg μικροενκαψυλιωμένης με
αιθυλοκυτταρίνη παρακεταμόλης που
αντιστοιχούν σε 500 mg
παρακεταμόλης σε κάθε δισκίο.
DEPON 200 mg υπόθετα: κάθε υπόθετο περιέχει
200 mg παρακεταμόλης.
DEPON 600 mg υπόθετα: κάθε υπό�
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| Trade Name | Depon |
| Availability | Rx and/or OTC |
| Generic | Acetaminophen |
| Acetaminophen Other Names | Acenol, Acetaminofén, Acetaminophen, Acétaminophène, APAP, Paracetamol, Paracétamol, Paracetamolum |
| Related Drugs | Buprenex, aspirin, ibuprofen, tramadol, cyclobenzaprine, Paracetamol, naproxen, diclofenac, Tylenol, oxycodone |
| Type | |
| Formula | C8H9NO2 |
| Weight | Average: 151.1626 Monoisotopic: 151.063328537 |
| Protein binding |
The binding of acetaminophen to plasma proteins is low (ranging from 10% to 25%), when given at therapeutic doses. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Cyprus, Greece |
| Last Updated: | September 19, 2023 at 7:00 am |
Depon
Depon (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.
Depon is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.
Animal and clinical studies have determined that acetaminophen has both antipyretic and analgesic effects. This drug has been shown to lack anti-inflammatory effects. As opposed to the salicylate drug class, acetaminophen does not disrupt tubular secretion of uric acid and does not affect acid-base balance if taken at the recommended doses. Depon does not disrupt hemostasis and does not have inhibitory activities against platelet aggregation. Allergic reactions are rare occurrences following acetaminophen use.
Uses
Depon is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
Depon injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.
Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.
Depon is also used to associated treatment for these conditions:
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergies, Ankylosing Spondylitis (AS), Arthritis, Chills, Cold, Cold Symptoms, Common Cold, Common Cold/Flu, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia Syndrome, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Nasal Congestion, Neuralgia, Osteoarthritis (OA), Pain, Pollen Allergy, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Soreness, Muscle, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Airway secretion clearance therapy, Antispasmodic, Bronchodilation
How Depon works
According to its FDA labeling, acetaminophen’s exact mechanism of action has not been fully established — despite this, it is often categorized alongside NSAIDs (nonsteroidal anti-inflammatory drugs) due to its ability to inhibit the cyclooxygenase (COX) pathways. It is thought to exert central actions which ultimately lead to the alleviation of pain symptoms.
One theory is that acetaminophen increases the pain threshold by inhibiting two isoforms of cyclooxygenase, COX-1 and COX-2, which are involved in prostaglandin (PG) synthesis. Prostaglandins are responsible for eliciting pain sensations. Depon does not inhibit cyclooxygenase in peripheral tissues and, therefore, has no peripheral anti-inflammatory effects. Though acetylsalicylic acid (aspirin) is an irreversible inhibitor of COX and directly blocks the active site of this enzyme, studies have shown that acetaminophen (paracetamol) blocks COX indirectly. Studies also suggest that acetaminophen selectively blocks a variant type of the COX enzyme that is unique from the known variants COX-1 and COX-2. This enzyme has been referred to as COX-3. The antipyretic actions of acetaminophen are likely attributed to direct action on heat-regulating centers in the brain, resulting in peripheral vasodilation, sweating, and loss of body heat. The exact mechanism of action of this drug is not fully understood at this time, but future research may contribute to deeper knowledge.
Depon
Table Of contents
- Depon
- Uses
- Dosage
- Side Effect
- Precautions
- Interactions
- Uses during Pregnancy
- Uses during Breastfeeding
- Accute Overdose
- Food Interaction
- Half Life
- Volume of Distribution
- Clearance
- Interaction With other Medicine
- Contradiction
- Storage
Toxicity
LD50 = 338 mg/kg (oral, mouse); LD50 = 1944 mg/kg (oral, rat)
Overdose and liver toxicity
Depon overdose may be manifested by renal tubular necrosis, hypoglycemic coma, and thrombocytopenia. Sometimes, liver necrosis can occur as well as liver failure. Death and the requirement of a liver transplant may also occur. Metabolism by the CYP2E1 pathway releases a toxic acetaminophen metabolite known as N-acetyl-p-benzoquinoneimine(NAPQI). The toxic effects caused by this drug are attributed to NAPQI, not acetaminophen alone.
Carcinogenesis
Long-term studies in mice and rats have been completed by the National Toxicology Program to study the carcinogenic risk of acetaminophen. In 2-year feeding studies, F344/N rats and B6C3F1 mice consumed a diet containing acetaminophen up to 6,000 ppm. Female rats showed evidence of carcinogenic activity demonstrated by a higher incidence of mononuclear cell leukemia at doses 0.8 times the maximum human daily dose (MHDD). No evidence of carcinogenesis in male rats (0.7 times) or mice (1.2 to 1.4 times the MHDD) was noted. The clinical relevance of this finding in humans is unknown.
Mutagenesis
Depon was not found to be mutagenic in the bacterial reverse mutation assay (Ames test). Despite this finding, acetaminophen tested positive in the in vitro mouse lymphoma assay as well as the in vitro chromosomal aberration assay using human lymphocytes. In published studies, acetaminophen has been reported to be clastogenic (disrupting chromosomes) when given a high dose of 1,500 mg/kg/day to the rat model (3.6 times the MHDD). No clastogenicity was observed at a dose of 750 mg/kg/day (1.8 times the MHDD), indicating that this drug has a threshold before it may cause mutagenesis. The clinical relevance of this finding in humans is unknown.
Impairment of Fertility
In studies conducted by the National Toxicology Program, fertility assessments have been performed in Swiss mice in a continuous breeding study. No effects on fertility were seen.
Use in pregnancy and nursing
The FDA label for acetaminophen considers it a pregnancy category C drug, meaning this drug has demonstrated adverse effects in animal studies. No human clinical studies in pregnancy have been done to this date for intravenous acetaminophen. Use acetaminophen only when necessary during pregnancy. Epidemiological data on oral acetaminophen use in pregnant women demonstrate no increase in the risk of major congenital malformations. While prospective clinical studies examining the results of nursing with acetaminophen use have not been conducted, acetaminophen is found secreted in human milk at low concentrations after oral administration. Data from more than 15 nursing mothers taking acetaminophen was obtained, and the calculated daily dose of acetaminophen that reaches the infant is about 1 to 2% of the maternal dose. Caution should be observed when acetaminophen is taken by a nursing woman.
Food Interaction
- Avoid alcohol. Alcohol may increase the risk of hepatotoxicity.
- Take with or without food. The absorption is unaffected by food.
Depon Alcohol interaction
[Major] GENERALLY AVOID:
Chronic, excessive consumption of alcohol may increase the risk of acetaminophen-induced hepatotoxicity, which has included rare cases of fatal hepatitis and frank hepatic failure requiring liver transplantation.
The proposed mechanism is induction of hepatic microsomal enzymes during chronic alcohol use, which may result in accelerated metabolism of acetaminophen and increased production of potentially hepatotoxic metabolites.
In general, chronic alcoholics should avoid regular or excessive use of acetaminophen.
Alternative analgesic/antipyretic therapy may be appropriate in patients who consume three or more alcoholic drinks per day.
However, if acetaminophen is used, these patients should be cautioned not to exceed the recommended dosage (maximum 4 g/day in adults and children 12 years of age or older).
Depon Drug Interaction
Unknown: aspirin, aspirin, diphenhydramine, diphenhydramine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, fluticasone nasal, fluticasone nasal, metoprolol, metoprolol, polyethylene glycol 3350, polyethylene glycol 3350, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, cetirizine, cetirizine
Volume of Distribution
Volume of distribution is about 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Depon appears to be widely distributed throughout most body tissues except in fat.
Elimination Route
Depon has 88% oral bioavailability and reaches its highest plasma concentration 90 minutes after ingestion.
Peak blood levels of free acetaminophen are not reached until 3 hours after rectal administration of the suppository form of acetaminophen and the peak blood concentration is approximately 50% of the observed concentration after the ingestion of an equivalent oral dose (10-20 mcg/mL).
The percentage of a systemically absorbed rectal dose of acetaminophen is inconsistent, demonstrated by major differences in the bioavailability of acetaminophen after a dose administered rectally. Higher rectal doses or an increased frequency of administration may be used to attain blood concentrations of acetaminophen similar to those attained after oral acetaminophen administration.
Half Life
The half-life for adults is 2.5 h after an intravenous dose of 15 mg/kg. After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen.
Clearance
Adults: 0.27 L/h/kg following a 15 mg/kg intravenous (IV) dose.
Children: 0.34 L/h/kg following a 15 mg/kg intravenous (IV dose).
Elimination Route
Depon metabolites are mainly excreted in the urine. Less than 5% is excreted in the urine as free (unconjugated) acetaminophen and at least 90% of the administered dose is excreted within 24 hours.
Innovators Monograph
You find simplified version here Depon
FAQ
What is Depon used for?
Depon is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever.
How safe is Depon?
When used as directed, taking Depon is generally safe and effective.
How does Depon work?
Depon relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before a person feels it. It reduces fever through its action on the heat-regulating center of the brain.
What are the common side effects of Depon?
Common side effects of Depon are include;
- nausea,
- stomach pain,
- loss of appetite,
- itching,
- rash,
- headache,
- dark urine,
- clay-colored stools,
- or jaundice (yellowing of skin or eyes).
Is Depon safe during pregnancy?
Depon as one of the only safe pain relievers for pregnant individuals during pregnancy.
Is Depon safe during breastfeeding?
Depon are safe to use when breastfeeding.
Can I drink alcohol with Depon?
Mixing Depon and alcohol can potentially lead to liver damage. Rarely, liver damage can be severe or even life-threatening.
Can I drive after taking Depon?
You should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. you should know that Depon and codeine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position.
How often can I take Depon?
Take every 4 to 6 hours, as needed, up to 4 times in a 24-hour period.
How do I take Depon?
Take Depon exactly as directed on the prescription or package label.
How much Depon can I take daily?
The usual dose is 325 mg to 650 mg. Take every 4 to 6 hours, as needed, up to 4 times in a 24-hour period. The maximum dose may vary from 3,000 mg to 4,000 mg, but do not take more than 4,000 mg in a 24-hour period.
How long does Depon take to work?
It usually takes about 45 minutes for oral, liquid, or tablet Depon to start working. The oral disintegrating tablets start to work in about 20 minutes.
What is the half life of Depon?
The Depon half-life was 5.4 hours (range, 0.8-119.7 hours).
How long can I take Depon?
Don’t take Depon for more than 10 days in a row unless you’ve been instructed to do so by your doctor.
Who should not take Depon?
You should not take Depon if you are allergic to it, or if you take other medications that contain acetaminophen. Ask a doctor or pharmacist if this medicine is safe to use if you’ve ever had cirrhosis of the liver, or if you drink alcohol daily.
What happens if I miss a dose?
Since Depon is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention. An overdose of acetaminophen can be fatal. The first signs of an Depon overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Should I stop taking Depon?
It is suggested that you stop taking Depon and talk with your doctor if: You still feel pain after 10 days (adult) or 5 days (children) You still have a fever after 3 days. Your symptoms get worse, or you feel new symptoms.
Can Depon affects my heart ?
It is not known to increase risks of heart attack, heart failure, or stroke.
Can Depon affect my kidneys?
Depon broken down/metabolized almost completely by the liver, so the kidneys hardly do any of the work and are not affected by it. Depon is safe for the kidneys.
Can Depon affects my liver?
Depon toxicity can quickly lead to liver damage. Liver damage associated with Depon use sends thousand of Americans to the hospital each year.