In this writeup, “ Alpha GPC for Depression” will be discussed, glimpse about depression and it’s a symptom, other names of GPCcholine, Alpha GPC and Depression, a side effect of Alpha GPC, Alpha GPC Dosage, Alternatives of Alpha GPC, interaction with Alpha GPC and finally with some FAQs regarding the topic.
Alpha GPC is used for depression because
- It helps in improving our memory.
- Combats fatigues and increase our stamina
- Mood Regulation and pleasure feeling
- Enhance our cognitive functioning.
- Boost our motivation
- Restore neurochemical balance
- Improves synaptic signalling and neuronal excitability
- Increase the production of both dopamine and acetylcholine.
- Improve mental and physical performance.
- Stimulate Groeth Hormone
Alpha GPC
Alpha GPC is a supplement that is taken to increase the level of acetylcholine in the brain. The full name is Alpha-Glycerophosphocholine. It is a cholinergic compound which has cognition promoting properties. Choline is present in the supplement which is also present in food. The supplement activates our cholinergic system which is preferred for cognitive aspects such as thinking, memory recall etc.
Depression
Depression is a mood disorder where the individual experience prolonged sadness, lethargic,
worthiness, helpless and melancholic that interferes or hampers their daily functioning. According to the World Health Organisation (2020), it is one of the most common mental disorder which affects 264 million people from different age group.
Unlike the mood swings which we experience normally, depression when it lasts long, it is a serious health condition, in the worst case, might result in suicide as well. The noting symptom is the profound sadness and the inability to experience pleasure, anhedonia. There are also physical symptoms associated; few of them are difficulty in the sleep cycle, psychomotor retardation, loss of appetite and tiredness.
Sign and Symptoms of Depression according to DSM5
According to the guidelines set in DSM 5, the following symptoms should be present in an individual for same 2 week period along with one symptom of either two: depressed mood and loss of interest, anhedonia.
- Depressed mood for most days
- Diminished interest in pleasurable activities
- Significant weight loss
- Disruption in appetite
- Insomnia and Hypersomnia
- Psychomotor Agitation
- Loss of energy and fatigue
- Diminished ability to think
- Recurrent thoughts on death and suicide
- Indecisiveness
- Excessive guilt
- Impairment in the social, professional and important area of life.
Other names for Alpha-GPC
Alpha GPC is known by different names such, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Choline alphoscerate, Glycérophosphorylcholine, GPC, GroPCho, L-alpha-glycerylphosphorylcholine, Alpha-glycerylphosphorylcholine, L–A-Glyceryl Phosphorylcholine.
Availability of Alpha-GPC
It is available in two forms, first one is oral via mouth while the other one is via a shot.
Working of Alpha GPC
Alpha GPC works by increasing Acetylcholine in our brain. It is the neurotransmitter that is responsible for our memory and learning. The supplement also works by delivering choline in the brain that increases acetylcholine production.
Acetylcholine is an important chemical for
- Learning
- Linguistic skill
- Reasoning and logic
- Creativity
- Memory
- Coordination and mobility
- Emotions
However, the concentration of this chemical declines with age naturally. Thus, to make sure that the cognitive functions are performing, one needs to keep the level of it high.
Choline
It is the essential ingredient in Alpha GPC and often found naturally in our body.
It is essential and needed for overall body functioning and health. Adding onto that, it is also important for our mental as well as physical performance.
While it is naturally present in our body, some of the choline-rich food are:
- Eggs
- Legumes
- Beef
- Vegetables
- Dairy products
Since the amount of Cholin present in ourself as well as food sources are usually low, Alpha GPC supplements are taken.
Alpha GPC and Depression
- Alpha GPC functions like Dopaminergic where it elevates our mood and pleasure sensation.
- It also stimulates the production of Growth Hormone that also improves our mood.
- Researches have shown that Alpha GPC supplements increase the level of both dopamine and Acetylcholine in the frontal cortex which subsequently improves our memory and learning.
- Increase in Acetylene as a result of supplement changes the neuronal network in the brain and thus modifies our inherent repose to both internal and external inputs.
- Researchers have found through researches that Alpha GPC change our cognition as well as increase TSH hormone associated with depression and thyroid.
Uses/ Benefits of Alpha GPC
Alpha GPC with its choline content is found to be effective in treating different illness as well as behavioural modifications.
Some of the uses of supplements are:
It supports our memory:
It boosts our memory by releasing acetylcholine and also slow down the process of memory loss. Choline helps in our ability to grasp new idea and concept.
Combat fatigue and tiredness
The supplement fight with fatigue by increasing our stamina. Our mood and stamina are highly correlated with increase acetylcholine level in the brain and body.
Mood Regulation
It has a positive effect on our pleasure sensation, incentive and mood. A study has proved that Alpha GPC has a positive effect or response to our dopamine production. Thus, it also helps in treating Parkinson disease caused by the low level of dopamine.
Preworkout benefits
Increase in stamina is related to improved performance in Athletic. The increased level of GHG as a result of Alpha GPC supplement improves our lower body force production. Because of it’s improved physical performance, alpha supplement is taken by fitness enthusiasts to improve their performance and is a popular pre-workout supplement.
Treating Alzheimer diseases and Stroke
Alpha GPC is used to treat Alzheimer where it improves the thinking skill of individual while it also results in better recovery of stroke.
Alpha GPC is Neuroprotective
It was shown and found through researches that Alpha GPC improves the overall cognition of an individual by also preventing cognitive degeneration. It has a significant positive effect on cognition.
The benefit of Alpha GPC for studying
It is a useful study aid for cognitive enhancement as well as attention, memory and mental performance.
Side Effect of Alpha GPC
Despite the use of Alpha GPC in the treatment of different disorders as well as for bodily process and functioning, there are numerous side effects associated with it. It is not safe to use for long term.
- Nervousness
- Diarrhoea
- Headache
- Heartburn
- Dizziness
- Skin rashes
- Insomnia
- Confusion
- Gastrointestinal issues
- Low Mood
- Low Blood Pressure
Dosage of Alpha GPC
- The appropriate use of Alpha GPC is determined by different factors such as age, health, and other health condition. Choline made up 40% of the Alpha-GPC.
- The standard dossage is 300-600mg.
- For most of the patient, the starting dose recommended by doctors is as low as 300 mg daily and then gradually working up to 600mg.
- For the treatment of cognitive decline, the standard dosage was 1200mg daily taken through three bits of 400mg.
Interaction with Alpha GPC
Scopolamine is a drug that interferes with the working of Alpha GPC because the latter increases the production of acetylcholine while Scopolamine blocks the production of the same.
Alpha GPC Alternatives
To receive a similar or equivalent benefit like Alpha GPC, certain medications can be taken. Some of those are:
Choline Bitartrate
It is the salt form of choline which is stable and metabolizes by the body. Both plant and animal organs contain choline bitartrate. It is anti-inflammatory thus, beneficial for our heart health.
Choline Citrate
It is a combination of choline and citrate where citrate activates the choline. It works by replenishing the body stores of choline and enhanced our energy and endurance.
Acetyl-L-Carnitine
It boosts our brainpower and enhance performance with a faster metabolism and build the muscle
Other than the mentioned ones, there are vitamin-B, Ginkgo Biloba, Ashwagandha that produces or result in similar benefit like Alpha GPC.
What we recommend for Depression
Professional counselling
If you are suffering from depression then ongoing professional counselling could be your ideal first point of call. Counselling will utilize theories such as Cognitive behavioural therapy which will help you live a more fulfilling life.
FAQs: Alpha GPC Depression
What is Alpha GPC good for?
It improves dementia, memory impairment, combat fatigue and mood regulation. On top of that, it is considered safe, available online and legal.
How much Alpha GPC should you take?
Ideally, 400-1200mg of Alpha GPC per day is optimal. One can always start with a low dose and increase gradually, however, should never overdose, doing which will cause tremendous and severe side effect.
How much choline is in Alpha GPC?
Choline makes up 40% of Alpha GPC which is similar to 1000mg of Alpha GPC containing 400mg of choline.
Is Alpha GPC a drug?
No, it is a supplement that is taken to improve our memory and cognitive functioning.
When to take Alpha GPC?
It can be taken at any time of the day, however, to get rid of the side effect, it is usually avoided before bed.
Can You Take Alpha GPC Every Day?
Yes, it is safe to take every day and people can tolerate it.
What is Alpha GPC good for?
The drug is administered to release acetylcholine and thus facilitate in our learning process as well as memory.
And for the athlete, the supplement prevents the reduction of choline while exercising, thus raise the endurance towards performance and increase growth hormone secretion.
Does Alpha GPC really work?
Yes, it is effective in increasing our body force production after days of medication. Sports coaches also add it to the diet of an athlete to increase their performance and strengthen the muscle.
Can you take Alpha GPC in empty stomach?
Yes, it is best absorbed when in empty stomach, however, in case of a sensitive stomach, it is advisable to take it with little food.
Is Alpha GPC natural?
Yes, it is a natural choline substance in the brain however, some supplements can be taken as well.
Does Alpha GPC increase dopamine?
Yes, it is proved through research that it increases the level of dopamine as well as acetylcholine while reducing TSH level.
Can too much choline be harmful?
Yes, excess choline will result in body odour, heavy sweating, vomiting, low blood pressure, salivation, etc.
How long does it take for choline to work?
Ideally, within an hour, the choline level in blood plasma is increased and the brain concentration reaches the apex in two hours.
Does choline cause anxiety?
No, Choline is negatively related to anxiety symptoms.
What does Alpha GPC feel like?
It is safe and tolerates in most of the individual, however, there are reported cases where individual feel headache, nausea and gets diahereea.
Conclusion
In this writeup, “ Alpha GPC Depression” was discussed, glimpse about depression and it’s a symptom, other names of GPCcholine, Alpha GPC and Depression, a side effect of Alpha GPC, Alpha GPC Dosage, Alternatives of Alpha GPC, interaction with Alpha GPC and finally with some FAQs regarding the topic.
Some sites for in-depth information
https://www.yourinception.com/alpha-gpc/
Alpha-GPC: Benefits, Dosing, Where To Buy, And More!
https://www.alzdiscovery.org/cognitive-vitality/ratings/alpha-gpc-choline-alfoscerate
Bibliography
Bjelland, I. (2009, 08 5). Choline in anxiety and depression: the Hordaland Health Study. PubMed.gov. https://pubmed.ncbi.nlm.nih.gov/19656836/
Gostincar, G. (2020, 8 1). Alpha GPC Review: 4 Amazing Benefits, Side Effects & More. your inception. https://www.yourinception.com/alpha-gpc/
Linder, L. (2018, 06). Alpha-GPC – An Overview. Klaire Lass. https://klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/
Marcus, L., & Soileau, J. (2017). Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance. Journal of the international society of sports and Nutrition, 14(39).
Onnit Research Team. (2020, 09 22). Alpha GPC Benefits, Uses, and Side Effects. Academy. Onnit Academy
Parker, A. G., Byars, A., & Purpura, M. (2015). The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Journal of International Society of Sports Nutrition, 12, 1550-2783.
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Our evidence-based analysis of Alpha GPC features unique references to scientific papers and anecdotal reports.
What Is Alpha GPC?
Alpha GPC is the common name for L-Alpha glycerylphosphorylcholine, a cholinergic nootropic that occurs naturally but can also be taken as a supplement.
Alpha GPC is best known for quickly and reliably delivering choline to the brain to create the cognition-boosting neurotransmitter acetylcholine.
It has powerful benefits for both the brain and body and may enhance the full range of cognitive functions, promote cellular health, and help maintain essential neurochemical balance in the brain.[1]
Alpha GPC is naturally present in the body in small amounts, and it is also commercially manufactured as a supplement using purified soy lecithin.
Though there are a few dietary sources of alpha GPC (most notably, dairy products, organ meats, and wheat germ), studies show that it only becomes pharmacologically active at high concentrations that are only attainable via supplementation.
Alpha GPC is available without a prescription as a dietary supplement in the US and Canada. In some European countries, it is regulated as a prescription drug and used to treat Alzheimer’s disease.
Alpha GPC is well known for its positive physical and mental effects, both when taken alone and in combination with other nootropics. Though many of its benefits are cognition-oriented and related to its cholinergic properties, it has also been shown to promote physical health and muscular strength.
Improved Memory and Enhanced Cognition
Alpha GPC’s ability to increase choline levels makes it an effective cognition enhancer, facilitating the production of the neurotransmitter acetylcholine.
This capability makes it of particular value in treating memory loss and cognition deficits related to neurological disorders.
Extensive clinical trials involving thousands of participants have shown it to be an effective treatment for memory loss associated with various age-related disorders, including Alzheimer’s disease, vascular dementia, and stroke.[2]
In Russia and some European countries, it is available as an oral or injectable prescription treatment for Alzheimer’s, sold under the brand names Gliatilin and Delecit and used to enhance memory, improve cognitive function, and help restore and maintain biochemical balance in the brain.
It is also prescribed to treat memory loss and cognition impairment related to stroke, traumatic brain injury, and dementia.[3]
Though most research has focused on age-related memory loss, alpha GPC’s memory benefits don’t seem limited to the elderly. In a study involving 32 healthy young volunteers, alpha GPC effectively restored memory following temporary chemically-induced amnesia.[4]
Anecdotal experience reports affirm that alpha GPC is an effective nootropic that provides a powerful cognitive boost, along with increased energy and motivation.[5][6][7]
Neuroprotectant
Alpha GPC has been shown to protect and support overall brain health by encouraging the development of new brain cells and enhancing the body’s ability to repair damaged cell membranes.
Research using animal models of vascular dementia shows that alpha GPC had a measurable neuroprotective effect.[8]
Other studies indicate it may also have neuroprotective anti-aging capabilities.[9]
Increased Strength and Rapid Post-Workout Recovery
Alpha GPC’s ability to stimulate the production of human growth hormone has not been extensively studied. Still, some believe it may improve the capacity to build lean muscle mass and recover more quickly after a workout.
A pilot study indicated that a 600 mg dose of alpha GPC, taken 90 minutes before bench pressing, increased power by 14%.[10]
Another small study involving eight healthy young men under 25 showed that a single dose of alpha GPC increased growth hormone secretion and hepatic fat oxidation, both of which are associated with increased energy and reduced recovery time.[11]
How It Works
Alpha GPC’s mechanisms of action have been extensively studied and are well understood, though how it affects some neuronal functions remains unclear.
Alpha GPC is structurally classified as a phosphatidylcholine, a lecithin phospholipid with a choline attachment. Choline is essential for the brain’s production of acetylcholine, the “learning neurotransmitter” that is crucial to all aspects of cognition. This function is at the heart of alpha GPC’s nootropic properties.
A water-soluble supplement, alpha GPC is both fast-acting and highly bioavailable when taken orally. It crosses the blood-brain barrier soon after ingestion, and most users notice effects within an hour. Each molecule of alpha GPC is made up of about 40% choline, which it delivers directly to the brain.[12]
Alpha GPC’s ability to cross the blood-brain border makes it a particularly efficient cholinergic, surpassing other cholinergics and even choline itself at increasing circulating levels of choline in the central nervous system.[13]
It has also been shown to increase levels of serotonin[14] and dopamine,[15] neurotransmitters that are important in the regulation of mood, energy, and motivation.
Alpha GPC also increases phosphatidylcholine levels throughout the body, which promotes strong cell structure, supports nerve signaling, and helps maintain the brain’s neurochemical balance.
Low levels of phosphatidylcholine are associated with neurological disorders, including Alzheimer’s disease,[16] dementia,[17] and schizophrenia.[18]
Dosage
The recommended dosage for alpha GPC, based on studies on its use in alleviating cognitive decline, is 1200 mg daily, divided into three doses of 400 mg.[19]
This is also the dosing recommendation for Glilitin, the Russian prescription form of alpha GPC.[20]
For most adults, the range of acceptable dosage is fairly wide; a cumulative daily dosage of 300–1200 mg taken in one to three doses has been documented as safe and effective.
Alpha GPC is generally well tolerated when taken at recommended dosages.
As is the case with all supplements, it is wise to start with the lowest possible effective dose and build up gradually as needed.
Stacking
Alpha GPC is an excellent choline source for use in stacks with other nootropics, particularly the racetams.
Alpha GPC, Noopept, Aniracetam Stack
Here’s an example of an alpha GPC stack that includes the popular nootropic Noopept and a racetam, aniracetam. This stack is designed for overall cognitive enhancement.
Review our article on how to create a nootropic stack for a general primer on basic combinations, ratios, and tips on designing your own nootropic stack.
Side Effects
While alpha GPC is both safe and well tolerated in healthy adults, some side effects have been reported.
Users have occasionally experienced headaches, fatigue, nervousness, nausea, diarrhea, and gastrointestinal distress.
Supplementing with alpha GPC may also result in dizziness and low blood pressure in some individuals; if you are prone to hypotension, you should consult a medical professional before taking alpha GPC.[21]
Though no overdoses have been documented, adverse side effects are more commonly reported among users taking high dosages.
Alpha GPC interacts with scopolamine, which is used to treat motion sickness, postoperative nausea, and irritable bowel syndrome. Those using scopolamine are advised to consult a physician before taking alpha GPC.
Little research has been done on alpha GPC’s effects on pregnant women, so those who are pregnant or nursing are advised to refrain from use.
Where to Buy
You can buy can alpha GPC from PureNootropics.net, our recommended supplier of nootropic supplements.
Alternatively, you can purchase alpha GPC on Amazon. We recommend the following brand for its high-quality products:
- Double Wood Supplements Alpha GPC Capsules
Closing Thoughts
Alpha GPC is a safe, well-tolerated, and highly effective nootropic.
It’s been the subject of decades of research. It is recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe and Russia for various memory and cognitive disorders.
Studies show that it’s also a neuroprotectant that helps maintain the biochemical balance of the brain. It promotes the production of human growth hormone, which may improve strength, shorten recovery time following exercise, and encourage the building of lean muscle mass.
If you’re interested in a supplement that’s affordable, readily available, and has well-documented benefits for both brain and body, alpha GPC supplementation may be worth a try.
Planning to start a new supplementation regimen? See our medical disclaimer.
This page was last updated on July 16, 2021.
Alpha GPC is a concentrated Choline B-Vitamin supplement. In this ultimate guide to Alpha GPC, you’re going to see many studies highlighting this compounds neurodevelopment and memory benefits.
You’ll also discover stacking ideas, alternatives, and understand how much Alpha GPC you need to take for optimal cognitive performance.
Table of Contents
- Quick overview of Alpha GPC
- What is Alpha GPC and Where Does it Come From?
- Studies on Brain Development
- Studies on Memory and Learning?
- Studies on Executive Function
- Studies on Energy, Attention and Motivation to Work
- Studies on Physical Power and Growth Hormones
- How to take Alpha GPC (Step-by-Step)
- What Stacks Well with Alpha GPC?
- Alpha GPC versus CDP Choline (Citicoline)
Quick overview of Alpha GPC
- Benefits: Primarily aiding in the development of brain-cells thanks to its Choline content.
- Actions: Metabolizes into the Choline B-Vitamin. Choline builds brain-cell membranes and creates the learning neurotransmitter Acetylcholine.
- Who is it good for? People who are Choline deficient (80% of the population) tend to get brain-fog. Also, those taking racetams should take a Choline supplement since racetams deplete Choline levels faster.
- Quality of studies: Choline has been thoroughly studied for over 20 years by Steven Zeisel (UNC) and Richard Wurtman (MIT). Neuroscience is in agreement that Alpha GPC is «essential to brain development» (University of Oxford)
- Time to effect: 3 months
- Stacks with: Uridine Monophosphate and DHA (found in omega-3) for enhanced Acetylcholine production and brain-cell repair
- Don’t stack with: Other Choline supplements like CDP Choline because you only need to reach the recommended daily intake.
- Recommended dose: Most people need 500mg-1000mg/day to reach the recommended daily intake. More details on how to calculate your ideal Alpha GPC dosage below.
What is Alpha GPC and Where Does it Come From?
Alpha GPC (L-Alpha glycerylphosphorylcholine) is a natural compound found in the brain. As a supplement, manufacturers extract Alpha GPC from Soy Lecithin.
1. Alpha GPC is effective at raising neural Choline levels
Alpha GPC is very effective at raising neural Choline levels. Choline has been widely studied to be integral to our cognition and overall brain development. Once ingested, it’s quick to cross the brain-blood barrier. In fact, a study found that it incorporated into the brain’s phospholipids of mice within 24 hours. Phoshpolipids are the raw materials we use to repair brain-cell membranes.
2. Alpha GPC contains twice the Choline content than CDP Choline
Alpha GPC is 40% Choline by weight. In other words, 1000mg of Alpha GPC would metabolize into 400mg of Choline. This is more than double the concentration of CDP Choline, which stands at 18.5% Choline. It’s also about the same as Choline bitartrate, which has a similar concentration of 40%.
As a nootropic, Alpha GPC is light years ahead of Choline bitartrate. Choline bitartrate, while cheaper, does not raise neural Choline levels. Alpha GPC does.
Studies on Brain Development
Alpha GPC’s nootropic qualities lie in its Choline B-Vitamin content. In an interview, Dr. Steven Zeisel from UNC said that Choline performs 2 key roles:
1. Choline builds the outer-wrapper of our brain-cells
Choline’s key role is creating Phospholipids, a type of fat that we use to form our brain cell’s outer wrappers called cell membranes. These hold our brain-cells together.
2. Choline creates our main chemical messenger Acetylcholine
Choline plays another critical role in connecting our brain-cells together. Not only does Choline repair brain-cells, it creates Acetylcholine. This is our main nerve messenger, according to Dr. Zeisel. Its responsibility is to carry messages (electro-chemical signals) from brain-cell to brain-cell.
People often call Acetylcholine the learning neurotransmitter. That’s because it’s often involved in sending messages to our memory center (hippocampus).
Studies on Memory and Learning
People oft en call Acetylcholine the learning neurotransmitter. That’s because it’s often involved in sending messages to our memory center (hippocampus). Here are some interesting results that researchers have seen regarding memory-gain:
1. Boosted immediate memory recall
The University of Milan saw Alpha GPC to benefit short-term and long-term memory. In one study, healthy men aged 18-39 saw immediate memory-recall gains. (2)
2. Alpha GPC creates the proteins necessary for long-term memory formation
Another study from the University of Milan saw increases in proteins associated with long-term memory (Protein Kinase C). When we form long-term memories, we use proteins to «solidify» the link in our neural network. Neuroscientists call this long-term potentiation. (3)
3. A correlation between Choline intake and verbal and visual memory
Boston University also found Choline intake to correlate with verbal and visual memory. This Framingham study included 1,371 healthy young men and women. (Boston University — 4)
Studies on Executive Function
Executive function means our ability to plan, organize and manage time. Things that require the use of our frontal cortex (the large area at the front of our brains).
1. Choline improves executive function and reaction times
University of Oslo researchers found Choline to improve executive function and mental processing. That includes things like planning, organizing and managing time.
They also saw Choline to boost sensory motor speed and perceptual speed. In other words, your awareness and the speed at which you react to stimuli.
Studies on Energy, Attention and Motivation to Work
1. Choline improves attention scores
University of Utah researchers found Choline to improve attention among healthy young women. (University of Utah — 6)
2. Choline boosted mental energy by 14%
Harvard Medical School found Choline improved mental energy by as much as 14%. (Harvard Medical School and McClean Hospital — 7)
3. Choline makes you more sensitive to the “motivation neurotransmitter” Dopamine
The University of Barcelona observed that Choline increases our sensitivity to Dopamine. This is significant to focus because dopamine is «motivation» at a chemical level. Brain-scans have shown that people with higher dopamine levels tend to be go-getters. (The University of Barcelona — 
4. Alpha GPC boosts Dopamine production
Researchers observed that Alpha GPC increases the activation of “striatal dopaminergic output”. So now you’re releasing more of the motivation chemical and you’re more sensitive to it. If you need to get things done, Choline can help you stay motivated to work harder at a chemical level. (Trabucchi M. — 9)
5. Higher Dopamine levels correlate with “go-getter” behaviour
Brain scans showed that people with higher dopamine levels tend to be “go-getters” and work harder. People with lower dopamine levels tend to be “slackers”. (Vanderbilt University — 10)
Studies on Physical Power and Growth Hormones
Alpha GPC is a unique Choline supplement because studies also suggest that it has a postive effect on our physical strength.
PS: It’s worth noting that if you are a professional athlete, check with the regulations to make sure taking Alpha GPC won’t get you flagged.
1. 1000mg of Alpha GPC was studied to significantly increase growth hormone after 65 minutes of ingestion. (Ritsumeikan University – 11)
2. 600mg of Alpha GPC 45 minutes before training increased athlete power output by 14% as assessed by bench throws. (Journal of the International Society of Sports Nutrition – 12)
3. “Alpha GPC is effective at increasing lower body force production after 6 days of supplementation. Sport performance coaches can consider adding A-GPC to the diet of speed and power athletes to enhance muscle performance.” (Journal of the International Society of Sports Nutrition – 12)
How to take Alpha GPC (Step-by-Step)
For most people, 500-1000mg of Alpha GPC every day will supply your brain with the Choline it needs for optimal brain-development and memory function.
The finer details and scientific reasoning behind this:
1. The Recommended daily Choline intake: The Linus Pauling Institute and the US institute of Medicine recommend that only a daily basis, men should get 550mg and women get 425mg of Choline.
2. Calculate your current Choline intake: Roughly work out your daily Choline intake from your diet. Most people tend to get around 200mg of Choline per day from their diet.
3. Understand how much Choline Alpha GPC gives you: Alpha GPC is 40% Choline by weight, which means that each 250mg Alpha GPC capsule would give you 100mg of Choline, 1 gram of Alpha GPC powder would give you 400mg of Choline and 1 gram of Alpha GPC 50% powder would give you 200mg of Choline.
4. Take your Alpha GPC: Take your Alpha GPC on a daily basis at different times of day (with gaps of 4-6 hours) to meet the recommended daily Choline intake. Alpha GPC has a half-life of 4-6 hours (this is how long it lasts in your body), which is why you should take it throughout the day instead of all at once.
5. Finding your optimal dosage: Some people have seen better results from exceeding the “official” recommended dose. According to Dr. Steven Zeisel, 10% of men would be better served by getting 850mg/day of Choline. All of our bodies break down Choline at different rates, so some people may need more.
7. Know your limit: If you produce too much Acetylcholine from too much Choline intake, you will get a headache or experience brain-fog. This won’t last long, but it’s a good indication of what your “limit” is.
What Stacks Well with Alpha GPC?
1. Uridine Monophosphate: Studies at MIT revealed that Uridine synergises extremely well with the Choline b-vitamin – the combination increases the production of neuron cell membranes and improves spatial awareness and selective attention.
2. Caffeine: Caffeine is seen to increase Acetylcholine release because it improves our ability to absorb Choline. “Coadministration of caffeine with choline significantly increased ACh release after each of the choline doses tested.” (Massachusetts Institute of Technology – 13)
3. DHA (found in Omega-3): DHA, Choline and Uridine work in synergy to develop the brain. When taken together, the production of phosphatidylcholine, used to build neuron cell membranes, increased by 45%.
Alpha GPC versus CDP Choline (Citicoline)
1. Alpha GPC contains more Choline than CDP Choline: Alpha GPC is 40% Choline by weight, whereas Citicoline is 18.5% Choline by weight. 250mg of Alpha GPC would provide 100mg of Choline. 250mg of Citicoline would provide 46mg of Choline. For strictly Choline supplementation, Alpha GPC tends to be the more popular choice.
2. Alpha GPC has a shorter half-life than CDP Choline: Alpha GPC lasts 4-6 hours in the body, whereas CDP Choline lasts 60-70 hours (roughly 3 days). As a result, Citicoline accumulates in the system.
3. Citicoline also breaks down into Uridine: But only at the plasma level. In other words, it’s not going to raise your neural (brain) Uridine levels that much. For this, you’d need to take Uridine Monophosphate.
References
- LPB Research Institute — https://www.ncbi.nlm.nih.gov/pubmed/8243501
- University of Milan — https://www.ncbi.nlm.nih.gov/pubmed/2071257?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
- University of Milan — https://www.ncbi.nlm.nih.gov/pubmed/8239301
- Boston University — http://ajcn.nutrition.org/content/94/6/1584.abstract?sid=3af7108c-0055-49f4-9dfb-52bd432c1dfd
- University of Oslo — https://www.ncbi.nlm.nih.gov/pubmed/22717142
- University of Utah — http://www.scirp.org/journal/PaperInformation.aspx?PaperID=19921#.VZrQM_lViko
- Harvard Medical School and McClean Hospital — https://www.ncbi.nlm.nih.gov/pubmed/18816480
- University of Barcelona — https://www.ncbi.nlm.nih.gov/pubmed/1839138
- Trabucchi M. — https://www.ncbi.nlm.nih.gov/pubmed/3709792
- Vanderbilt University — https://news.vanderbilt.edu/2012/05/01/dopamine-impacts-your-willingness-to-work/
- Ritsumeikan University – https://www.ncbi.nlm.nih.gov/pubmed/22673596
- Journal of the International Society of Sports Nutrition — https://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15
- Massachusetts Institute of Technology — https://www.ncbi.nlm.nih.gov/pubmed/1435067
Альфа-ГФХ (L-альфа-глицерилфосфорилхолин) представляет собой ноотропную добавку, обладающую целым рядом преимуществ для когнитивной функции. Это один из самых известных и хорошо изученных ноотропов, который, как было показано, улучшает память, концентрацию и внимание.
Alpha GPC доступен в капсулах, таблетках и порошках. Обычно его принимают в дозах 300–600 мг, и лучшее время для приема — за 30–60 минут до задач, требующих когнитивных функций.
Alpha GPC обычно считается безопасным, но побочные эффекты могут включать головную боль, головокружение и расстройство желудочно-кишечного тракта. Если вы испытываете какие-либо из этих побочных эффектов, вам следует уменьшить дозу или полностью прекратить прием добавки.
Что говорят эксперты:
Общего мнения об идеальной дозе Alpha GPC нет, но большинство экспертов рекомендуют принимать от 200 до 600 мг в день. Лучший способ принять Alpha GPC — разделить дозу на две или три меньшие дозы, принимаемые в течение дня. Например, вы можете принимать 200 мг утром, 200 мг днем и 200 мг вечером.
«Alpha GPC — это натуральная добавка холина, которая, как было показано, улучшает память и когнитивные функции. Также было показано, что она повышает уровень нейротрансмиттера ацетилхолина.
Ацетилхолин участвует во многих когнитивных процессах, включая обучение и память.
Считается, что альфа-ГФХ работает за счет повышения уровня ацетилхолина в головном мозге. Это достигается за счет увеличения количества холина, доступного мозгу для синтеза ацетилхолина.
Alpha GPC доступен в виде добавок и часто используется в качестве ноотропа или усилителя когнитивных функций.
Важно отметить, что альфа-ГФХ не следует путать с другой аналогичной добавкой, ЦДФ-холином (цитидиндифосфат-холин). Хотя они оба повышают уровень ацетилхолина, они работают по разным механизмам.
Alpha GPC считается безопасным и хорошо переносимым. Наиболее частым побочным эффектом являются головные боли, что часто связано с тем, что альфа-ГПХ может вызывать временное повышение артериального давления.
Если вы планируете принимать альфа-GPC, обязательно сначала поговорите со своим врачом, чтобы узнать, подходит ли он вам».
Alpha GPC побочные эффекты
1. Головная боль
2. Бессонница
3. Тошнота
4. Диарея
5. Беспокойство
6. Головокружение
7. Сердцебиение
8. Гипертония
9. Тремор
10. Мышечная слабость
Alpha GPC запретили?
Некоторые эксперты считают, что использованию альфа-ГПХ может угрожать разработка новых препаратов, способных имитировать его эффекты. Эти препараты, известные как ноотропы, предназначены для улучшения когнитивных функций и памяти. Хотя в настоящее время они недоступны в Соединенных Штатах, они могут стать более популярными по мере того, как станут более широко доступными. Если это произойдет, это может привести к снижению спроса на альфа-ГПХ.
Alpha GPC польза
Альфа-ГФХ (L-альфа-глицерилфосфорилхолин) представляет собой природное холинсодержащее соединение, которое содержится в головном мозге. Он является предшественником нейротрансмиттера ацетилхолина и участвует в синтезе фосфолипидов, необходимых для клеточных мембран. Альфа-ГФХ используется в качестве пищевой добавки для улучшения памяти и когнитивных функций, и в клинических испытаниях он показал многообещающие результаты для лечения болезни Альцгеймера и других форм деменции.
Alpha GPC аналог
Аналоги альфа-ГФХ представляют собой аналогичные соединения, которые можно использовать для повышения уровня ацетилхолина или для лечения болезни Альцгеймера и других когнитивных расстройств. Эти аналоги можно принимать перорально или вводить в виде инъекций, и они, как правило, хорошо переносятся и имеют мало побочных эффектов.
Alpha GPC и DMAE
-Alpha GPC — это ноотропная добавка, которая, как утверждается, улучшает когнитивные функции и память.
-ДМАЭ — это органическое соединение, которое, как утверждается, улучшает когнитивные функции.
-Alpha GPC и DMAE часто комбинируют в добавках, потому что считается, что они работают синергетически.
– Есть некоторые доказательства того, что Alpha GPC может улучшать когнитивные функции у здоровых взрослых, но необходимы дополнительные исследования.
Было показано, что ДМАЭ улучшает когнитивные функции у стареющих взрослых, но, опять же, необходимы дополнительные исследования.
– Нет никаких доказательств того, что комбинация Alpha GPC и DMAE дает какие-либо дополнительные преимущества.
Performance
Alpha GPC 99%
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Take 2 capsules up to 2 times daily with food, or as directed by your healthcare professional.
TQ 5 Point Testing Program
Every Toniiq product lot is third-party tested for:
✔ Microbiology and Presence of Heavy Metals in Raw Material
✔ Assay of Active Ingredient in Raw Material
✔ Assay of Active Ingredient in Finished Product
✔ Fill Weight in Finished Product
✔ Microbiology and Presence of Heavy Metals in Finished Product
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Benefits
For Brain Support & Cognition
Helps support cognitive function, mental acuity, and memory
For Acetylcholine Production
Supports increased synthesis of acetylcholine
For Cell Support
Supports cell membranes
The Ingredients That Matter
Our Alpha GPC supplement is carefully extracted to ensure a minimum of 99% purity, making it highly potent and bioavailble. With a 600mg serving that delivers the equivalent Alpha GPC content of two capsules from other brands, this Alpha GPC supplement is one of the most powerful options available in the market.
99% Highly Purified
600mg per Serving
3rd Party Lab Tested
Leading Brand
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Savings
Alpha GPC 99%
$44.00
$23.97
+$20.03
- Поддержка когнитивных функций
- Биодоступный источник холина
- Поддерживает мозговую деятельность
- Соответствует стандарту качества GMP
- Пищевая добавка
- Растительная формула
Альфа-ГФХ — это природный физиологический прекурсор ацетилхолина — нейротрансмиттера, участвующего в деятельности памяти и других когнитивных функциях. Альфа-ГФХ — это более биодоступная форма холина, которая отлично всасывается, становится составной частью клеточных мембран мозга и нервных тканей и пересекает гематоэнцефалический барьер. Клинические исследования показали, что добавки с Альфа-ГФХ увеличивают синтез ацетил-холина в мозгу, что помогает поддерживать когнитивные функции и мозговую деятельность.
Рекомендации по применению
Принимать по 2 капсулы два раза в день во время еды. Лучше всего принимать в начале дня.
Ингредиенты
Целлюлоза (капсула), целлюлозный порошок, диоксид кремния, стеариновая кислота (растительного происхождения) и стеарат магния (растительного происхождения).
Содержит: сою (альфа-ГФХ из соевого лецитина).
При производстве не используются дрожжи, пшеница, глютен, молоко, яйца, рыба, ракообразные и древесные орехи. Производится на предприятии, соответствующем стандартам GMP, где выполняется обработка других ингредиентов, содержащих эти аллергены.
Предупреждения
Продукт может естественным образом менять цвет. После вскрытия упаковки хранить в сухом и прохладном месте.
Только для взрослых. Перед применением во время беременности, лактации, приема лекарств или при наличии каких-либо заболеваний следует проконсультироваться с врачом. Хранить в недоступном для детей месте. Силикагель нельзя употреблять в пищу. Хранить во флаконе.