Торговое название:
- Абимол Экстра
- Abimol Extra
Состав:
Каждая таблетка содержит:
- Парацетамол – 500 мг
- Кофеин безводный – 30 мг
Вспомогательные компоненты:
Крахмал, повидон, тальк, калия сорбит, кислота стеариновая, натрия кроскармеллоза.
Свойства:
Препарат оказывает обезболивающее и жаропонижающее действие.
«Абимол Экстра» содержит комбинацию двух активных ингредиентов парацетамола и кофеина. Парацетамол блокирует циклооксигеназу (ЦОГ) в ЦНС, воздействуя на центры боли и терморегуляции (в воспаленных тканях клеточные пероксидазы нейтрализуют влияние парацетамола на ЦОГ), что объясняет практически полное отсутствие противовоспалительного эффекта. Отсутствие влияния на синтез Рg в периферических тканях обусловливает отсутствие у него отрицательного влияния на водно-солевой обмен (задержка натрия и воды) и слизистую ЖКТ. Кофеин стимулирует психомоторные центры головного мозга, оказывает аналитическое действие, усиливает эффект анальгетиков, устраняет сонливость и чувство усталости, повышает физическую и умственную работоспособность.
Показания:
- Головная боль;
- Мигрень;
- Зубная боль;
- Боль в пояснице;
- Нвралгия;
- Мышечная и ревматическая боль;
- Блезненные менструации;
- Боль в горле;
- Симптоматическое лечение простудных заболеваний и гриппа (снижение повышенной температуры тела).
Способ применения:
Таблетки «Абимол Экстра» принимают внутрь, обычно 1-2 таблетки 3-4 раза в сутки, если необходимо. Интервал между приемами – не менее 4 часов. Максимальная разовая доза – 2 таблетки, максимальная суточная доза – 8 таблеток.
Препарат не рекомендуется применять более пяти дней как обезболивающее и более трех дней как жаропонижающее без назначения и наблюдения врача.
Противопоказания:
- повышенная чувствительность к компонентам препарата выраженные нарушения функции печени или почек
- отсутствие глюкозо-6-фосфатдегидрогеназы
- заболевания крови
- значительная артериальная гипертензия, выраженные явления атеросклероза
- беременность и период грудного вскармливания
- с осторожностью следует применять при синдроме Жильбера (конституциональная гипербилирубинемия)
- глаукома, нарушения сна
- детский возраст до 14 лет.
Меры предосторожности:
При приеме в течение длительного времени препарат усиливает действие непрямых антикоагулянтов (варфарин и другие кумарины), что увеличивает риск кровотечений. Индукторы микросомального окисления печени (барбитураты, фенитоин, этанол, рифампицин, фенилбутазон, трициклические антидепрессанты) повышают риск гепатотоксического действия при передозировках. Ингибиторы микросомального окисления (циметидин) снижают риск гепатотоксического действия. Под воздействием парацетамола время выведения хлорамфеникола увеличивается в 5 раз. Кофеин ускоряет всасывание эрготамина.
Побочные эффекты:
В рекомендованных дозах препарат обычно хорошо переносится. Парацетамол редко вызывает побочные эффекты. Может наблюдаться аллергические реакции в виде высыпаний на коже, зуда, отека Квинке. Редко – лейкопения, тромбоцитопения, метгемоглобинемия, агранулоцитоз, а также нарушение сна, тахикардия.
При длительном применении в высоких дозах повышается вероятность гепатотоксического и нефротоксического действия и необходим контроль картины крови.
Хранение:
Хранить при температуре не выше 30 градусов.
Упаковка:
Картонная коробка вмещает 2 блистера по 10 таблеток, бумажную инструкцию.
Торговое название:
Абимол
Abimol
Состав:
Каждая капсула содержит:
Парацетамол 500 мг
Вспомогательные компоненты:
Крахмал, поливинилпирролидон, магния стеарат, кросповидон.
Свойства:
Анальгетик-антипиретик. Обладает анальгезирующим, жаропонижающим и слабым противовоспалительным действием. Механизм действия связан с ингибированием синтеза простагландинов, преимущественным влиянием на центр терморегуляции в гипоталамусе.
Показания:
Болевой синдром слабой и умеренной интенсивности различного генеза (в т. ч. головная боль, мигрень, зубная боль, невралгия, миалгия, альгодисменорея; боль при травмах, ожогах). Лихорадка при инфекционно-воспалительных заболеваниях.
Способ применения и дозы:
Максимальные дозы для взрослых: разовая — 1 г, суточная — 4 г. Разовые дозы для приема внутрь для детей в возрасте 6-12 лет — 250-500 мг, 1-5 лет — 120-250 мг.
Кратность применения — 4 раза/сут с интервалом не менее 4 ч. Максимальная продолжительность непрерывного лечения — 3 дня.
Максимальная доза: 4 разовые дозы в сутки.
Противопоказания:
Хронический алкоголизм, повышенная чувствительность к парацетамолу.
Меры предосторожности:
С осторожностью применяют у пациентов с нарушениями функции печени и почек, с доброкачественной гипербилирубинемией, а также у больных пожилого возраста.
При длительном применении парацетамола необходим контроль картины периферической крови и функционального состояния печени.
Побочные эффекты:
Со стороны пищеварительной системы: редко — диспептические явления, при длительном применении в высоких дозах — гепатотоксическое действие.
Со стороны системы кроветворения: редко — тромбоцитопения, лейкопения, панцитопения, нейтропения, агранулоцитоз.
Аллергические реакции: редко — кожная сыпь, зуд, крапивница.
Способ хранения:
Хранить при температуре не выше 30 градусов.
Упаковка:
Картонная коробка вмещает 2 блистера по 10 таблеток, бумажную инструкцию.
Состав:
Применение:
Применяется при лечении:
Артралгия,Болезненная менструация,Боли в спине,Боль,Боль в горле,Боль в ухе,Головная боль,Грипп,Зубная боль,Лихорадка,Мигрень,Мышечные Боли,Напряженная головная боль,Невралгия,Простуда,Синдром Прорезывания Зубов
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Топ 20 лекарств с такими-же компонентами:
Топ 20 лекарств с таким-же применением:
Название медикамента
Предоставленная в разделе Название медикамента Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
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Abimol
Состав
Предоставленная в разделе Состав Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
внимательны и обязательно уточняйте информацию по разделу Состав
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Acetaminophen
Терапевтические показания
Предоставленная в разделе Терапевтические показания Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
внимательны и обязательно уточняйте информацию по разделу Терапевтические показания
в инструкции к лекарству Abimol непосредственно из упаковки или у фармацевта в аптеке.
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Суспензия для приема внутрь
Таблетки
У детей с 3 мес (от 1 до 3 мес применение Abimolа по всем показаниям возможно только по назначению врача) до 6 лет в качестве жаропонижающего средства (ОРВИ, грипп, детские инфекции, поствакцинальные реакции и другие состояния, сопровождающиеся повышенной температурой тела) и болеутоляющего средства (болевой синдром слабой и умеренной интенсивности, в т.ч. головная и зубная боль, боль в мышцах, невралгия, боль при травмах и ожогах).
Болевой синдром слабой или умеренной интенсивности (головная боль, невралгия, миалгия, артралгия, альгодисменорея, зубная боль), понижение повышенной температуры тела при инфекционно-воспалительных заболеваниях (в т.ч. простудных).
Способ применения и дозы
Предоставленная в разделе Способ применения и дозы Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
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Драже; Суспензия для приема внутрь для детей
Суспензия для приема внутрь
Таблетки
Внутрь. Взрослым по 500 мг до 4 раз в сутки, максимальная разовая доза — 1 г, суточная — 4 г. Курс не более 5 дней. Детям по 10–15 мг/кг каждые 6 ч, курс 3–5 дней.
Внутрь, запивая большим количеством жидкости, через 1–2 ч после приема пищи 3–4 раза в сутки с интервалом не менее 4 ч.
Суспензию Abimol для детей не следует разводить. Для удобства и точности дозирования используют мерную ложку, отмеряющую 2,5 и 5 мл суспензии.
Рекомендуемые дозы для детей от 3 мес до 6 лет
| Возраст | Разовые дозы |
| 3 мес — 1 год | 60–120 мг парацетамола (2,5–5 мл) |
| От 1 года до 6 лет | 120–240 мг парацетамола (5–10 мл) |
Продолжительность лечения: 3 дня в качестве жаропонижающего и до 5 дней в качестве болеутоляющего средства. При необходимости продолжения приема препарата требуется консультация врача.
Внутрь, предпочтительнее между приемами пищи, шипучую таблетку полностью растворяют в стакане воды, а полученный раствор сразу выпивают. Если врачом не даны другие указания, то при применении препарата следует соблюдать следующие дозировки:
взрослые: по 500–1000 мг (1–2 шипучие таблетки) 3–4 раза в сутки, максимальная доза — 4 г/сут.
дети: дозировка по массе тела ребенка подразумевает прием дозы 10–15 мг/кг. Удобная схема дозировок приведена в таблице.
| Возраст | Масса тела, кг | Разовая доза, мг | Максимальная суточная доза, г |
| 6–9 лет | 22–30 | 250 (0,5 табл.) | 1–1,5 (2–3 табл.) |
| 9–12 лет | до 40 | 500 (1 табл.) | 2 (4 табл.) |
| старше 12 лет | >40 | 500–1000 (1–2 шипучих табл.) | 2–4 (4–8 табл.) |
Рекомендуемый интервал между приемами — 6–8 ч (не менее 4 ч). Максимальная продолжительность лечения для детей — 3 дня, для взрослых — не более 5 дней при назначении в качестве обезболивающего средства и не более 3 дней при назначении в качестве жаропонижающего средства. После 5 дней лечения проводят анализ периферической крови.
Противопоказания
Предоставленная в разделе Противопоказания Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
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Суспензия для приема внутрь
Таблетки
Гиперчувствительность, тяжелые нарушения функции печени, почек, заболевания крови, дефицит глюкозо-6-фосфатдегидрогеназы, грудной возраст до 1 мес.
Повышенная чувствительность к компонентам препарата, почечная и печеночная недостаточность, дефицит глюкозо−6-фосфатдегидрогеназы, беременность, кормление грудью, детский возраст до 6 лет.
Побочные эффекты
Предоставленная в разделе Побочные эффекты Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
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Суспензия для приема внутрь
Таблетки
Тошнота, рвота, боли в животе, аллергические реакции (кожная сыпь, зуд, крапивница, отек Квинке); редко — тромбоцитопения, агранулоцитоз, лейкопения, анемия; при длительном применении в больших дозах — гепатотоксическое и нефротоксическое действие, панцитопения, метгемоглобинемия.
Аллергические реакции — кожная сыпь, зуд, крапивница, отек Квинке; тошнота, боль в эпигастрии; анемия, тромбоцитопения. При длительном применении в больших дозах — гепатотоксическое действие, нефротоксическое действие (почечная колика, асептическая пиурия, интерстициальный нефрит, папиллярный некроз), гемолитическая анемия, апластическая анемия, метгемоглобинемия, панцитопения, агранулоцитоз. Очень редко — понижение АД, гипогликемия, диспноэ, васкулит.
Передозировка
Предоставленная в разделе Передозировка Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
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Суспензия для приема внутрь
Таблетки
Симптомы: бледность, потливость, боль в желудке, тошнота и рвота, через 1–2 сут — признаки поражения печени (болезненность в области печени, повышение активности печеночных ферментов в крови, увеличение протромбинового времени). В тяжелых случаях — печеночная недостаточность, гепатонекроз, энцефалопатия, коматозное состояние.
Лечение: прекращение приема препарата, промывание желудка, назначение энтеросорбентов (активированный уголь, полифепан), в/в введение антидота — N-ацетилцистеина или назначение внутрь метионина.
Симптомы: бледность кожных покровов, анорексия, тошнота, рвота; гепатонекроз (выраженность некроза вследствие интоксикации прямо зависит от степени передозировки).
Лечение: промывание желудка, назначение активированного угля.
Фармакодинамика
Предоставленная в разделе Фармакодинамика Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
внимательны и обязательно уточняйте информацию по разделу Фармакодинамика
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Обладает чрезвычайно малым влиянием на синтез ПГ в периферических тканях, не изменяет водно-солевой обмен (задержка натрия и воды) и не повреждает слизистую ЖКТ.
Фармакокинетика
Предоставленная в разделе Фармакокинетика Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
внимательны и обязательно уточняйте информацию по разделу Фармакокинетика
в инструкции к лекарству Abimol непосредственно из упаковки или у фармацевта в аптеке.
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Суспензия для приема внутрь
Таблетки
Cmax в плазме достигается через 30–90 мин после приема внутрь. Величина соотношения объема распределения и биодоступности у детей и новорожденных подобна таковым у взрослых. T1/2 — 1,5–2,5 ч. Метаболизируется в печени. У новорожденных и детей до 10 лет основным метаболитом является сульфат парацетамола, у детей 12 лет и старше — конъюгированный глюкуронид. При недостатке глутатиона эти метаболиты могут блокировать ферментные системы гепатоцитов и вызывать их некроз. Примерно 85–95% дозы выводится с мочой за 24 ч (менее 4% препарата — в неизмененном виде).
Абсорбция высокая, связывание с белками плазмы — 15%. Cmax в плазме достигается через 0,5–2 ч. Проходит через ГЭБ, проникает в грудное молоко (менее 1% от принятой дозы). Эффективная терапевтическая концентрация в плазме достигается при назначении в дозе 10–15 мг/кг.
Метаболизируется в печени: 80% конъюгирует с глюкуроновой кислотой и сульфатами с образованием неактивных метаболитов, 17% гидроксилируется с образованием активных метаболитов, которые конъюгируют с глутатионом и образуют неактивные метаболиты. При недостатке глутатиона эти метаболиты могут блокировать ферментные системы гепатоцитов и вызывать их некроз. Т1/2 — 2–3 ч, у пожилых пациентов клиренс препарата снижается и увеличивается период полувыведения. Выводится почками — 3% в неизмененном виде.
Фармокологическая группа
Предоставленная в разделе Фармокологическая группа Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
внимательны и обязательно уточняйте информацию по разделу Фармокологическая группа
в инструкции к лекарству Abimol непосредственно из упаковки или у фармацевта в аптеке.
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- Анилиды
Взаимодействие
Предоставленная в разделе Взаимодействие Abimolинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Abimol. Будьте
внимательны и обязательно уточняйте информацию по разделу Взаимодействие
в инструкции к лекарству Abimol непосредственно из упаковки или у фармацевта в аптеке.
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Суспензия для приема внутрь
Таблетки
Алкоголь, барбитураты, трициклические антидепрессанты, противосудорожные препараты, фенилбутазон, рифампицин усиливают гепатотоксичность, салицилаты — нефротоксическое действие.
Парацетамол усиливает действие непрямых антикоагулянтов, снижает эффективность урикозурических препаратов, повышает токсичность хлорамфеникола.
Стимуляторы микросомального окисления в печени (фенитоин, этанол, барбитураты, рифампицин, фенилбутазон, трициклические антидепрессанты, эстрогенсодержащие контрацептивы) увеличивают продукцию гидроксилированных активных метаболитов, что обусловливает возможность развития тяжелых интоксикаций при небольших передозировках. Этанол способствует развитию острого панкреатита. Ингибиторы микросомального окисления (циметидин) снижают риск гепатотоксического действия. Снижает эффективность урикозурических препаратов. Усиливает действие препаратов, угнетающих ЦНС, этанола. При замедлении опорожнения желудка (пропантелин) может иметь место замедленное наступление действия парацетамола, а при ускорении (метоклопрамид) — препарат начинает действовать быстрее. Усиливается токсичность хлорамфеникола. Следует соблюдать осторожность при продолжительном применении парацетамола и одновременной терапии пероральными препаратами, тормозящими свертывание крови.
Abimol цена
У нас нет точных данных по стоимости лекарства.
Однако мы предоставим данные по каждому действующему веществу
Средняя стоимость Acetaminophen 500 mg за единицу в онлайн аптеках от 0.16$ до 0.31$, за упаковку от 21$ до 31$.
Средняя стоимость Acetaminophen 120 mg за единицу в онлайн аптеках от 2.05$ до 2.05$, за упаковку от 25$ до 25$.
Средняя стоимость Acetaminophen 325 mg за единицу в онлайн аптеках от 0.21$ до 0.21$, за упаковку от 21$ до 21$.
Средняя стоимость Acetaminophen 650 mg за единицу в онлайн аптеках от 2.3$ до 2.3$, за упаковку от 28$ до 28$.
Источники:
- https://www.drugs.com/search.php?searchterm=abimol
- https://pubmed.ncbi.nlm.nih.gov/?term=abimol
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Name of the medicinal product
The information provided in Name of the medicinal product of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Name of the medicinal product in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Abimol
Qualitative and quantitative composition
The information provided in Qualitative and quantitative composition of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Qualitative and quantitative composition in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Acetaminophen
Therapeutic indications
The information provided in Therapeutic indications of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
For the treatment of mild to moderate pain including headache, migraine, neuralgia, toothache, sore throat, period pains, aches and pains, symptomatic relief of rheumatic aches and pains and of influenza, feverishness and feverish colds.
Abimol ActiFast is a mild analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine and tension headaches, toothache, backache, rheumatic and muscle pains, dysmenorrhoea, sore throat, and for relieving the fever, aches and pains of colds and flu.
Abimol Infant Sugar Free Colour Free 120 mg/5 ml Oral Suspension is indicated for the treatment of mild to moderate pain and as an antipyretic. It can be used in many conditions including headache, toothache, earache, teething, sore throat, colds and influenza, aches and pains and post-immunisation fever.
Dosage (Posology) and method of administration
The information provided in Dosage (Posology) and method of administration of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Adults, the elderly and young persons 16 years and over:
2 tablets every 4 hours to a maximum of 8 tablets in 24 hours.
Children 6 — 9 years:
½ tablet every 4 hours to a maximum of 4 doses in 24 hours.
Children 10 — 11 years:
1 tablet every 4 hours to a maximum of 4 doses in 24 hours
Adolescents 12 — 15 years:
1 to 1 ½ tablets every 4 hours to a maximum of 4 doses in 24 hours
Do not give to children aged under 6 years of age.
For oral administration.
Adults, including the elderly and children 16 years and over:
Two tablets to be taken with half a tumbler of water (100 ml).
To ensure fast onset of pain relief no less than two tablets must be taken with 100 ml of water. For maximum speed of action this should be on an empty stomach.
Two tablets up to four times daily as required. The dose should not be repeated more frequently than every four hours nor should more than four doses be taken in any 24 hour period.
Children aged 12-15 years:
One tablet to be taken with half a tumbler of water (100ml), up to four times daily as required. The dose should not be repeated more frequently than every four hours nor should more than 4 doses be given in any 24 hour period.
Children under 12 years of age:
Abimol ActiFast is not recommended for children under 12 years of age.
For the relief of fever after vaccinations at 2, 3 and 4 months
2.5ml. This dose may be given up to 4 times a day starting at the time of vaccination. Do not give more than 4 doses in any 24 hour period. Leave at least 4 hours between doses. If your baby still needs this medicine two days after receiving the vaccine talk to your doctor or pharmacist.
|
Age : 2 — 3 months |
Dose |
|
Pain and other causes of fever — if your baby weighs over 4 kg and was born after 37 weeks |
2.5 ml If necessary, after 4-6 hours, give a second 2.5 ml dose |
|
— Do not give to babies less than 2 months of age. — Leave at least 4 hours between doses. — Do not give more than 2 doses. This is to ensure that fever that may be due to a serious infection is quickly diagnosed. If your child is still feverish after two doses, talk to your doctor or pharmacist. |
Children aged 3 months — 6 years:
|
Child’s Age |
How Much |
How often (in 24 hours) |
|
3 — 6 months |
2.5 ml |
4 times |
|
6 — 24 months |
5 ml |
4 times |
|
2 — 4 years |
7.5 ml (5 ml + 2.5 ml) |
4 times |
|
4 — 6 years |
10 ml (5 ml + 5 ml) |
4 times |
|
— Do not give more than 4 doses in any 24 hour period — Leave at least 4 hours between doses — Do not give this medicine to your child for more than 3 days without speaking to your doctor or pharmacist |
It is important to shake the bottle for at least 10 seconds before use.
The Elderly:
In the elderly, the rate and extent of paracetamol absorption is normal but plasma half-life is longer and paracetamol clearance is lower than in young adults.
Contraindications
The information provided in Contraindications of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Hypersensitivity to Abimol or any of the constituents.
Hypersensitivity to paracetamol or any of the other constituents.
Special warnings and precautions for use
The information provided in Special warnings and precautions for use of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Care is advised in the administration of Abimol to patients with severe renal or severe hepatic impairment. The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease.
Do not take more medicine than the label tells you to. If you do not get better, talk to your doctor.
Contains Abimol.
Do not take anything else containing Abimol while taking this medicine.
Talk to your doctor at once if you take too much of this medicine, even if you feel well. This is because too much Abimol can cause delayed, serious liver damage.
Patients should be advised that Abimol may cause severe skin reactions. If a skin reaction such as skin reddening, blisters, or rash occurs, they should stop use and seek medical assistance right away.
Care is advised in the administration of paracetamol to patients with renal or hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.
Do not exceed the stated dose.
Patients should be advised not to take other paracetamol-containing products concurrently.
Each Abimol ActiFast tablet contains 173 mg of sodium and should not be taken by patients on a low sodium diet.
Patients should be advised to consult their doctor if their headaches become persistent.
If symptoms persist consult your doctor.
Keep out of the reach and sight of children.
Pack Label:
Immediate medical advice should be sought in the event of an overdose, even if you feel well.
Do not take with any other paracetamol-containing products.
Patient Information Leaflet:
Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.
Abimol Infant Sugar Free Colour Free 120 mg/5 ml Oral Suspension should be used with caution in severe renal impairment or severe hepatic impairment. The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease.
Concomitant use of other paracetamol-containing products should be avoided.
Due to the presence of maltitol liquid (E965) and sorbitol liquid (E420), patients with rare hereditary problems of fructose intolerance should not take this medicine.
Ethyl (E214), Propyl (E216) and Methyl (E218) parahydroxybenzoate may cause allergic reactions (possibly delayed).
Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity.
The label contains the following statements:
Contains paracetamol.
Do not give anything else containing paracetamol while giving this medicine.
Do not give more medicine than the label tells you to. If your child does not get better, talk to your doctor.
For oral use only.
Always use the syringe supplied with the pack.
Do not give to babies less than 2 months of age.
For infants 2-3 months no more than 2 doses should be given.
Do not give more than 4 doses in any 24 hour period.
Leave at least 4 hours between doses.
Do not give this medicine to your child for more than 3 days without speaking to your doctor or pharmacist.
As with all medicines, if your child is currently taking any other medicine consult your doctor or pharmacist before using this product.
Keep out of the sight and reach of children.
Do not store above 25°C. Keep bottle in the outer carton.
It is important to shake the bottle for at least 10 seconds before use.
Talk to a doctor at once if your child takes too much of this medicine, even if they seem well.
The leaflet contains the following statements:
Talk to a doctor at once if your child takes too much of this medicine, even if they seem well. This is because too much paracetamol can cause delayed, serious liver damage.
Talk to your doctor: If your child has an inherited intolerance to fructose or been diagnosed with an intolerance to some other sugars.
The sorbitol liquid (E420) and maltitol liquid (E965) content of this product means that this product is unsuitable for people with inherited intolerance to fructose.
Very rare cases of serious skin reactions have been reported. Symptoms may include:
— Skin reddening
— Blisters
— Rash
If skin reactions occur or existing skin symptoms worsen, stop use and seek medical help right away.
Effects on ability to drive and use machines
The information provided in Effects on ability to drive and use machines of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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None.
Undesirable effects
The information provided in Undesirable effects of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Adverse effects of Abimol are rare. Very rare cases of serious skin reactions have been reported. There have been reports of blood dyscrasias including thrombocytopenia purpura, methaemoglobenaemia and agranulocytosis, but these were not necessarily causality related to Abimol.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
Adverse events of paracetamol from historical clinical trial data are both infrequent and from small patient exposure. Accordingly, events reported from extensive post-marketing experience at therapeutic/labelled dose and considered attributable are tabulated below by system class. Due to limited clinical trial data, the frequency of these adverse events is not known (cannot be estimated from available data), but post-marketing experience indicates that adverse reactions to paracetamol are rare and serious reactions are very rare.
Post marketing data
|
Body System |
Undesirable effect |
|
Blood and lymphatic system disorders |
Thrombocytopenia Agranulocytosis |
|
Immune system disorders |
Anaphylaxis Cutaneous hypersensitivity reactions including skin rashes, angiodema and Stevens Johnson syndrome/toxic epidermal necrolysis |
|
Respiratory, thoracic and mediastinal disorders |
Bronchospasm* |
|
Hepatobiliary disorders |
Hepatic dysfunction |
* There have been cases of bronchospasm with paracetamol, but these are more likely in asthmatics sensitive to aspirin or other NSAIDs.
Adverse effects of paracetamol are rare but hypersensitivity/anaphylactic reactions including skin rash may occur. Very rare cases of serious skin reactions have been reported. There have been reports of blood dyscrasias including thrombocytopenia and agranulocytosis but these were not necessarily causally related to paracetamol.
Most reports of adverse reactions to paracetamol relate to overdose with the drug.
Chronic hepatic necrosis has been reported in a patient who took daily therapeutic doses of paracetamol for about a year and liver damage has been reported after daily ingestion of excessive amounts for shorter periods. A review of a group of patients with chronic active hepatitis failed to reveal differences in the abnormalities of liver function in those who were long-term users of paracetamol nor was the control of their disease improved after paracetamol withdrawal.
Nephrotoxicity following therapeutic doses of paracetamol is uncommon, but papillary necrosis has been reported after prolonged administration.
Low level transaminase elevations may occur in some patients taking therapeutic doses of paracetamol; these are not accompanied with liver failure and usually resolve with continued therapy or discontinuation of paracetamol.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
Overdose
The information provided in Overdose of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Liver damage is possible in adults who have taken 10g or more of Abimol. Ingestion of 5g or more of Abimol may lead to liver damage if the patient has risk factors (see below).
Risk Factors
If the patient
a) Is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John’s Wort or other drugs that induce liver enzymes.
Or
b) Regularly consumes ethanol in excess of recommended amounts.
Or
c) Is likely to be glutathione deplete e.g. eating disorders, cystic fibrosis, HIV infection, starvation, cachexia.
Symptoms
Symptoms of Abimol overdosage in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema, and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.
Management
Immediate treatment is essential in the management of Abimol overdose. Despite a lack of significant early symptoms, patients should be referred to hospital urgently for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. Management should be in accordance with established treatment guidelines, see BNF overdose section.
Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma Abimol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable).
Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of Abimol however, the maximum protective effect is obtained up to 8 hours post ingestion.
If required the patient should be given intravenous-N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital.
Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.
Liver damage is possible in adults who have taken 10g or more of paracetamol. Ingestion of 5g or more of paracetamol may lead to liver damage if the patient has risk factors (see below).
Risk factors
If the patient
a, Is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John’s Wort or other drugs that induce liver enzymes.
Or
b, Regularly consumes ethanol in excess of recommended amounts.
Or
c, Is likely to be glutathione deplete e.g. eating disorders, cystic fibrosis, HIV infection, starvation, cachexia.
Symptoms
Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema, and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.
Management
Immediate treatment is essential in the management of paracetamol overdose. Despite a lack of significant early symptoms, patients should be referred to hospital urgently for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. Management should be in accordance with established treatment guidelines, see BNF overdose section.
Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with the NPIS or a liver unit.
High doses of sodium bicarbonate may be expected to induce gastrointestinal symptoms including belching and nausea. In addition, high doses of sodium bicarbonate may cause hypernatraemia; electrolytes should be monitored and patients managed accordingly.
Liver damage is possible in adults who have taken 10g or more of paracetamol. Ingestion of 5g or more of paracetamol may lead to liver damage if the patient has risk factors (see below)
Risk Factors:
If the patient
a) Is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John’s Wort or other drugs that induce liver enzymes
OR
b) Regularly consumes ethanol in excess of recommended amounts
OR
c) Is likely to be glutathione deplete e.g, eating disorders, cystic fibrosis, HIV infection, starvation, cachexia
Symptoms
Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, hyperhidrosis, malaise, vomiting, anorexia, and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. This may include hepatomegaly, liver tenderness, jaundice, acute hepatic failure and hepatic necrosis. Abnormalities of glucose metabolism and metabolic acidosis may occur. Blood bilirubin, hepatic enzymes, INR, prothrombin time, blood phosphate and blood lactate may be increased. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.
Management
Immediate treatment is essential in the management of paracetamol overdose. Despite a lack of significant early symptoms, patients should be referred to hospital urgently for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of the overdose or the risk of organ damage. Management should be in accordance with established treatment guidelines, see BNF overdose section.
Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentrations should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patient who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with the NPIS or a liver unit.
Pharmacodynamic properties
The information provided in Pharmacodynamic properties of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Mechanisms of Action/Effect
Analgesic — the mechanism of analgesic action has not been fully determined. Abimol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and to a lesser extent, through a peripheral action by blocking pain-impulse generation.
The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitise pain receptors to mechanical or chemical stimulation.
Antipyretic — Abimol probably produces antipyresis by acting centrally on the hypothalamic heat-regulation centre to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus.
ATC Code N02B E01
Paracetamol has analgesic and antipyretic actions. The mechanism of action is based on the inhibition of prostaglandin biosynthesis.
Paracetamol is poorly absorbed in the stomach but well absorbed in the small intestine due to the greater surface area and hence adsorptive capacity.
Sodium bicarbonate is an excipient in the formulation which has a role in increasing the rates of gastric emptying and of paracetamol dissolution and hence the speed of absorption of paracetamol to provide faster onset of relief.
The amount of sodium bicarbonate contained in 2 tablets of Abimol ActiFast are required per dose to have such effects. Sodium bicarbonate influences the rate of gastric emptying in a concentration dependant manner with the maximal effect achieved at near isotonic concentrations (150 mmol/litre)(i.e. 150 millimolar) — equivalent to 2 Abimol ActiFast tablets in 100 ml water.
Hypertonic solutions (500-1,000 mmol/litre)(i.e. 500 to 1,000 millimolar — equivalent to the amount of sodium bicarbonate in 6-12 Abimol ActiFast tablets given with 100 ml water) appear to inhibit gastric emptying. The therapeutic application of enhanced gastric emptying has previously been demonstrated with significantly faster rate of absorption of paracetamol and significantly faster onset of pain relief from soluble tablets containing sodium bicarbonate compared to conventional tablets. Abimol ActiFast has been formulated with 630 mg sodium bicarbonate per tablet that results in near isotonicity at a 2-tablet dose in gastric fluid.
The role of the dissolution rate of Abimol ActiFast Tablets in vivo at gastric pH is unknown. Therefore the role of tablet dissolution in the speed of action of Abimol ActiFast Tablets is unclear.
It is likely that no single mode of action is responsible for the pharmacokinetic profile observed with Abimol ActiFast. The relative contributions of the different factors will vary depending on the circumstances under which the product is taken.
Pharmacotherapeutic group: Other Analgesics and Antipyretics (Anilides)
ATC Code: N02 BE01
Paracetamol has analgesic and antipyretic effects similar to those of aspirin and is useful in the treatment of mild to moderate pain. It has only weak anti-inflammatory effects.
Pharmacokinetic properties
The information provided in Pharmacokinetic properties of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
Absorption and Fate
Abimol is readily absorbed from the gastro-intestinal tract with peak plasma concentrations occurring about 30 minutes to 2 hours after ingestion. It is metabolised in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged Abimol. The elimination half-life varies from about 1 to 4 hours. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations.
A minor hydroxylated metabolite which is usually produced in very small amounts by mixed-function oxidases in the liver and which is usually detoxified by conjugation with liver glutathione may accumulate following Abimol overdosage and cause liver damage.
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. It is metabolised in the liver and excreted in the urine as the glucuronide and sulphate conjugates, — less than 5% is excreted unchanged in the urine as unmodified paracetamol. Binding to plasma proteins is minimal.
The mean elimination half-life of paracetamol following administration of Abimol ActiFast is 2 to 3 hours and is similar to that achieved following administration of standard paracetamol tablets in fasted and fed states.
Following administration of Abimol ActiFast, paracetamol has a median time to peak plasma concentrations (tmax) of 25 minutes in fasted subjects and 45 minutes in the fed subjects. Maximum plasma concentrations were reached at least twice as fast for Abimol ActiFast as for standard paracetamol tablets in both the fed and fasted state (p= 0.0002). Following administration of Abimol ActiFast, paracetamol is generally measurable in plasma within 10 minutes in both the fed and fasted state.
Two tablets of Abimol ActiFast are required to be taken with 100 ml of water to obtain this fast rate of absorption of paracetamol. The maximum rate of absorption is obtained on an empty stomach. When one tablet is taken the rate of absorption of paracetamol for Abimol ActiFast is the same as for standard paracetamol tablets. This is thought to be due to insufficient sodium bicarbonate present in the single tablet dose to increase the rate of paracetamol absorption. In addition, tablets taken with insufficient (<100 mls) water are unlikely to have increased speed of action. (See 5.1 Pharmacodynamic properties).
The extent of absorption of paracetamol from Abimol ActiFast tablets is equivalent to that of standard paracetamol tablets as shown by AUC in both fed and fasted states.
Absorption
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached 30-90 minutes post dose and the plasma half-life is in the range of 1 to 3 hours after therapeutic doses.
Distribution
Drug is widely distributed throughout most body fluids.
Biotransformation
Metabolism occurs almost entirely via hepatic conjugation with glucuronic acid (about 60%), sulphuric acid (about 35%) or cysteine (about 3%). Small amounts of hydroxylated and deacetylated metabolites have also been detected.
Children have less capacity for glucuronidation of the drug than do adults.
In overdosage there is increased N-hydroxylation followed by glutathione conjugation. When the latter is exhausted, reaction with hepatic proteins is increased leading to necrosis.
Elimination
Following therapeutic doses 90-100% of the drug is recovered in the urine within 24 hours.
Pharmacotherapeutic group
The information provided in Pharmacotherapeutic group of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Other Analgesics and Antipyretics (Anilides)
Preclinical safety data
The information provided in Preclinical safety data of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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Pills; Rectal suppositories; Rectal suppositories for children; Solution for infusion; Substance; Substance-powder; Syrup; Tablets, effervescent
Bolus; Coated tablet; Effervescent tablet; Film-coated tablet; Tablets, soluble
Suspension for ingestion for children
None stated
Preclinical safety data on paracetamol in the literature have not revealed any findings which are of relevance to the recommended dosage and use of the product and which have not been mentioned in other sections of the SmPC.
Mutagenicity
There are no studies relating to the mutagenic potential of Abimol Infant Sugar Free Colour Free 120 mg/5 ml Oral Suspension.
In vivo mutagenicity tests of paracetamol in mammals are limited and show conflicting results. Therefore, there is insufficient information to determine whether paracetamol poses a mutagenic risk to man.
Paracetamol has been found to be non-mutagenic in bacterial mutagenicity assays, although a clear clastogenic effect has been observed in mammalian cells in vitro following exposure to paracetamol (3 and 10 mM for 2h).
Carcinogenicity
There are no studies to the carcinogenic potential of Abimol Infant Sugar Free Colour Free 120 mg/5 ml Oral Suspension.
There is inadequate evidence to determine the carcinogenic potential of paracetamol in humans. A positive association between the use of paracetamol and cancer of the ureter (but not of other sites in the urinary tract) was observed in a case-control study in which approximate lifetime consumption of paracetamol (whether acute or chronic) was estimated. However, other similar studies have failed to demonstrate a statistically significant association between paracetamol and cancer of the urinary tract, or paracetamol and renal cell carcinoma.
There is limited evidence for the carcinogenicity of paracetamol in experimental animals. Liver cell tumours can be detected in rats following chronic feeding of 500 mg/kg/day paracetamol.
Teratogenicity
There is no information relating to the teratogenic potential of Abimol Infant Sugar Free Colour Free 120 mg/5 ml Oral Suspension. In humans, paracetamol crosses the placenta and attains concentrations in the foetal circulation similar to those in the maternal circulation. Intermittent maternal ingestion of therapeutic doses of paracetamol are not associated with teratogenic effects in humans.
Paracetamol has been found to be foetotoxic to cultured rat embryo.
Fertility
A significant decrease in testicular weight was observed when male Sprague-Dawley rats were given daily high doses of paracetamol (500 mg/kg/body weight/day) orally for 70 days.
Incompatibilities
The information provided in Incompatibilities of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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None known
Special precautions for disposal and other handling
The information provided in Special precautions for disposal and other handling of Abimol
is based on data of another medicine with exactly the same composition as the Abimol.
. Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Abimol directly from the package or from the pharmacist at the pharmacy.
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No special requirements for disposal.
Abimol price
We have no data on the cost of the drug.
However, we will provide data for each active ingredient
The approximate cost of Acetaminophen 500 mg per unit in online pharmacies is from 0.16$ to 0.31$, per package is from 21$ to 31$.
The approximate cost of Acetaminophen 120 mg per unit in online pharmacies is from 2.05$ to 2.05$, per package is from 25$ to 25$.
The approximate cost of Acetaminophen 325 mg per unit in online pharmacies is from 0.21$ to 0.21$, per package is from 21$ to 21$.
The approximate cost of Acetaminophen 650 mg per unit in online pharmacies is from 2.3$ to 2.3$, per package is from 28$ to 28$.
Available in countries
Find in a country:
| Trade Name | abimol |
| Generic | Paracetamol |
| Paracetamol Other Names | Acenol, Acetaminofén, Acetaminophen, Acétaminophène, APAP, Paracetamol, Paracétamol, Paracetamolum |
| Type | |
| Formula | C8H9NO2 |
| Weight | Average: 151.1626 Monoisotopic: 151.063328537 |
| Protein binding |
The binding of acetaminophen to plasma proteins is low (ranging from 10% to 25%), when given at therapeutic doses. |
| Therapeutic Class | Non opioid analgesics |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
abimol
abimol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
abimol (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme’s active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
Uses
abimol IV is used for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, the reduction of fever.
abimol is a non-salicylate antipyretic and non-opioid analgesic agent. abimol IV injection is a sterile, clear, colorless, non pyrogenic, isotonic formulation of abimol intended for intravenous infusion.
abimol is also used to associated treatment for these conditions:
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergies, Ankylosing Spondylitis (AS), Arthritis, Chills, Cold, Cold Symptoms, Common Cold, Common Cold/Flu, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia Syndrome, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Nasal Congestion, Neuralgia, Osteoarthritis (OA), Pain, Pollen Allergy, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Soreness, Muscle, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Airway secretion clearance therapy, Antispasmodic, Bronchodilation
abimol
Table Of contents
- abimol
- Uses
- Dosage
- Side Effect
- Precautions
- Interactions
- Uses during Pregnancy
- Uses during Breastfeeding
- Accute Overdose
- Food Interaction
- Half Life
- Volume of Distribution
- Clearance
- Interaction With other Medicine
- Contradiction
- Storage
Dosage
abimol dosage
Adults and adolescents weighing 50 kg and over: the recommended dosage of abimol IV is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of abimol IV of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of abimol of 4000 mg per day.
Adults and adolescents weighing under 50 kg: the recommended dosage of abimol IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of abimol IV of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of abimol of 75 mg/kg per day.
Children >2 to 12 years of age: the recommended dosage of abimol IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of abimol IV of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of abimol of 75 mg/kg per day.
Side Effects
As all paracetamol products, adverse drug reactions are rare (>1/10000, <1/1000) or very rare (<1/10000). Frequent adverse reactions at injection site have been reported during clinical trials (pain and burning sensation). Very rare cases of hypersensitivity reactions ranging from simple skin rash or urticaria to anaphylactic shock have been reported and require discontinuation of treatment. Cases of erythema, flushing, pruritus and tachycardia have been reported.
Precaution
Administration of abimol in doses higher than recommended may result in hepatic injury, including the risk of severe hepatotoxicity and death. Do not exceed the maximum recommended daily dose of abimol. Use caution when administering abimol in patients with the following conditions: hepatic impairment or active hepatic disease, alcoholism, chronic malnutrition, severe hypovolemia (e.g., due to dehydration or blood loss), or severe renal impairment (creatinine clearance < 30 ml/min). There were infrequent reports of life-threatening anaphylaxis requiring emergent medical attention. Discontinue abimol IV immediately if symptoms associated with allergy or hypersensitivity occurs. Do not use abimol IV in patients with abimol allergy.
Food Interaction
- Avoid alcohol. Alcohol may increase the risk of hepatotoxicity.
Volume of Distribution
Volume of distribution is about 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Acetaminophen appears to be widely distributed throughout most body tissues except in fat.
Half Life
The half-life for adults is 2.5 h after an intravenous dose of 15 mg/kg. After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen.
Clearance
Adults: 0.27 L/h/kg following a 15 mg/kg intravenous (IV) dose. Children: 0.34 L/h/kg following a 15 mg/kg intravenous (IV dose).
Pregnancy & Breastfeeding use
Pregnancy Category C. There are no studies of intravenous abimol in pregnant women; however, epidemiological data on oral abimol use in pregnant women show no increased risk of major congenital malformations. Animal reproduction studies have not been conducted with IV abimol and it is not known whether abimol IV can cause fetal harm when administered to a pregnant woman. abimol IV should be given to a pregnant woman only if clearly needed. There are no adequate and well-controlled studies with abimol IV during labor and delivery; therefore, it should be used in such settings only after a careful benefit-risk assessment. While studies with abimol IV have not been conducted, abimol is secreted in human milk in small quantities after oral administration.
Contraindication
abimol is contraindicated in patients with known hypersensitivity to its active ingredient or to any of the excipients in the intravenous formulation. Also contraindicated in patients with severe hepatic impairment or severe active liver disease
Special Warning
Pediatric Use: The safety and effectiveness of abimol IV for the treatment of acute pain and fever in pediatric patients ages 2 years and older is supported by evidence from adequate and well-controlled studies of abimol IV in adults.
Geriatric use: No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients.
Patients with Hepatic Impairment: abimol is contraindicated in patients with severe hepatic impairment or severe active liver disease and should be used with caution in patients with hepatic impairment or active liver disease. A reduced total daily dose of abimol may be warranted.
Patients with Renal Impairment: In cases of severe renal impairment (creatinine clearance < 30 ml/min), longer dosing intervals and a reduced total daily dose of abimol may be warranted.
Storage Condition
Store in a cool & dry place & away from children. For single use only. The product should be used within 6 hours after opening. Do not refrigerate or freeze.
Innovators Monograph
You find simplified version here abimol
FAQ
What is abimol?
abimol is a common painkiller used to treat aches and pain. It can also be used to reduce a high temperature. It’s available combined with other painkillers and anti-sickness medicines. It’s also an ingredient in a wide range of cold and flu remedies.
What are side effects of abimol?
- Skin rash that may include itchy, red, swollen, blistered or peeling skin.
- Wheezing.
- Tightness in the chest or throat.
- Trouble breathing or talking.
- Mouth, face, lips, tongue or throat start swelling.
How safe is abimol?
abimol is known to cause liver failure in overdose, but it also causes liver failure in people taking standard doses for pain relief. The risk is only about one in a million, but it is a risk. All these different risks stack up.
What are the types of abimol?
Types of abimol
- tablets or caplets.
- capsules.
- liquid – usually for children.
- soluble tablets (tablets that dissolve in water to make a drink)
- suppositories (capsules inserted into the back passage)
- an injection given into a vein – normally only used in hospital.
What happens if I take abimol without any reason?
Even taking one or two more tablets than recommended can cause serious liver damage and possibly death. abimol overdose is one of the leading causes of liver failure.
Why is abimol bad for our liver?
abimol itself is not toxic, but in large amounts it overwhelms the body’s ability to process it safely. This can lead to build up of a toxic metabolite (or break-down product), which binds to liver cells, causing these cells to die.
What are the indications of abimol?
This abimol is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
What happens if I take abimol on an empty stomach?
Ibuprofen, aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs) can irritate the stomach lining, so it is best to take them with food, or a glass of milk. abimol doesn’t irritate the stomach lining so it won’t matter if you haven’t eaten.
Can abimol help I sleep?
A successful result is one where the pain is reduced by half or more, or where they have no or only mild pain. That result delivers not just on pain, but also improves sleep, depression, quality of life, work, and the ability to get on with life.
How is abimol eliminated from the body?
abimol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 30 minutes to 2 hours after ingestion. It is metabolised in the liver (90-95%) and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged abimol.
Is abimol is safe during pregnancy?
abimol is the first choice of painkiller if you’re pregnant. abimol been taken by many pregnant women with no harmful effects in the mother or baby.
Is abimol safe during breastfeeding?
abimol is the first choice of painkiller if you’re breastfeeding women. It’s been taken by many breastfeeding women with no harmful effects in the mother or baby.
How does abimol work?
abimol seems to work by blocking chemical messengers in the brain that tell us we have pain. It also reduces fever by affecting the chemical messengers in an area of the brain that regulates body temperature.
When will I feel better after taking abimol?
abimol takes up to an hour to work. It keeps on working for about 5 hours.
Can I take abimol for a long time?
It’s safe to take abimol regularly for many years as long as you don’t take more than the recommended dosage.
Will abimol affect my fertility?
There’s no firm evidence to suggest that taking abimol will reduce fertility in either men or women.
Will abimol affect my contraception?
abimol doesn’t affect any type of contraception including the contraceptive pill or emergency contraception.
Can I drink alcohol with abimol?
Drinking a small amount of alcohol while taking abimol is usually safe. Try to keep to the recommended guidelines of no more than 14 units of alcohol a week. A standard glass of wine (175ml) is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol.
Is there any food or drink I need to avoid when taking abimol?
You can eat and drink normally while taking abimol. You can safely take abimol (but not ibuprofen) on an empty stomach.
Abimol
Paracetamol
Composition :
– Tablet containing 500 mg of Paracetamol
– Syrup each Srnl contains 150mg of Paracetamol
– Each Suppository contains 300 mg of Paracetamol
Pharmaceutical Form :
Tablet, Syrup & Suppository
Pharmacological Action :
Mild analgesic and anttpvretic. and is recommended for the treatment of most painful and febrile conditions.
Pharmacokinetics :
Paracetamol is rapidly and almost completely absorbed from the gastrointestinaJ tract. The concentration in plasma reaches a peak in 30 to 90 minutes and the plasma half-life IS 1 – 4 hours after therapeutic doses, Paracetamol is relativtely uniformly distributed throughout most body fluids. Binding of the drug to plasma proteins is variable; 20 to 30% may be bound at the concentrations encountered during acute intoxication. Following therapeutic doses 90 – 100% of the drug may be recovered in the urine within the first day. However, practicaflv no paracetamol is excreted unchanged and the bulk is excreted after hepatic conjugation.
Pharmacokinetics in Renal Impairment :
An increase in the interval between doses of paracetamol has been recommended for adults with chronic renal failure.Haemodialysis may result in reduced plasma levels of paracetamol and therefore supplementary doses of paracetamol maybe necessary in order to maintain therapeutic blood levels.
Pharmacokinetics in Hepatic Impairment :
In mild liver disease, there is-no evidence that paracetamol is harmful when taken at recommended doses. However, in severe fiver disease. the plasma paracetamol half-life is significantly prolonged
Indication :
Analgesic and antipyretic. and is recommended for the treatment of most painful and febrile conditions, for example headache including migraine and tension headaches. toothache , backache. rheumatic and muscle pains. dysmenorrhoea, sore throat. and for relieving the fever, aches and pains of colds and flu. Also recommended for the symptomatic relief of pain due to non-serious arthritis.
Dosage & Administration :
Adults:
One to two tablets every 4 to 6 hours up to four times daily as required. Maximum daily dose is 4000 mg. Do not exceed the
stated dose. Do not take more than 8 tablets in 24 hours. Do not take more frequently than every four hours
Children: Children should not be givt:n Abimol for more than 3 days without consulting a doctor. No more than 4 doses tobe taken in any 24 hour period. The maximum daily dose is 60 mg/Kg
6 – 12 years: Half to one tablet three or four times daily as required.
1 – 6 years: 5 to 10 ml of the liquid suspension (120 to 240 mg of paracetamol). Dose may be repeated after 4 hours.
3 months to less than 1 year: 2.5 to 5 ml of the liquid suspension (GO to 120 mg of paracetamol). Dose may be repeated after 4 hours.
less than 3 months: 2.5ml of the liquid suspension may be administered to infants who develop pyrexia after vaccination at
2 months of age. If necessary. a second dose can be given 4-6 hours later. If pvrexia persists after the second dose, medical attention is required.
For all other indications in this age group, use only under medical supervision.
Abimol should not be used with other paracetamol containing products.
Contra-Indications :
Abimol is contraindicated in patients with a previous history of hypersensitivity to paracetamol or excipients.
Side Efftects :
– Paracetamolhas been widely used and, when taken at the usual recommended dosage. side effects are mild and infrequent and reports of adverse reactions are rare.
– Skin rash and other allergic reactions, such as anqioedema occur rarely.
– In patients sensitive to aspirin or other NSAIDs. aggravation of bronchospasm has been reported.
– Most reports of adverse reactions to paracetamol relate to overdose with the drug.
– Isolated cases of blood dyscrasia. thrombocytopenic purpura. haemolytic anaemia and agranulocytosis have been recorded.
– chronic hepatic necrosis has been reported in a patient who took daily therapeutic doses of paracetamol for about a year and liver damage has been reported after daily ingestion of excessive amounts for shorter periods. A review of a group of patients with chronic active hepatitis failed to revee! differences in the abnormalities of tlver function in those who were long-term users of paracetamol nor was the control of their disease improved after paracetamol withdrawal.
– Nephrotoxic effects following therapeutic doses of peracetemol are uncommon. Papillary necrosis has been reported after prolonged administration
Over dose & treatment :
– Potentially fatatflver damage is likely in adults who have taken 159 or more of paracetamol. As little as 109 may lead to livernecrosis, Patients taking enzyme-inducing drugs or with a history of alcoholism may have an increased SUSttptibility. It is considered that excess quantities of a toxic metebolite (usually adequately detoxified by glutathione when normal d<RS of paracetamol art employed), become irreversibly bound to liver tissue.
– Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, diarrhoea, anorexia, abdominal pain
and increased sweating. over damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur ln severe poisoning, hepatic failure may progress to encephalocathv, coma, and death. Acute renat failure with acute tubular necrosis may develop even in the absence of severe livtr damage. Cardiac arrhythmias have been reported.
– Prompt treatment is essential in the management of paracetamol overdosage Any patient who has ingested about 7.5g or more of paracetamol in the preceding 4 hours should undergo gastric lavage or induced emesis. Specific therapy with an antidote such as acttyfcysteint: or methionine may be necessary, Acetylcysteine may be given either intravenously or by mouth or methionine may be givtn by mouth within 10 -12 hours of ingestion of the overdose. Generally treatment is required if the blood-paracetamol concentration is higher than a line (the ‘200’ line) drawn on semi- log/linear paper joining th( points 200 mg/litre (1.32 mmol/litrt) at 4 hours and 30 mg/litrt (0.20 mmol/litre.) at 15 hours following ingestion.
– Determination of the concentration before 4 hours is not considered to give a reliable measurement, Administration of oral
methionine or intravenous N-acttylcystt:ine which may have a beneficial effect up to at least 48 hours after the overdose,may be I’tquired. General supportive measures must be. available. Ilver function tests should be. performed at 24 hour intervals for at least 96 hours post-ingestion if the plasma parecetamot concentration indicates a potential for hepatotoxicity. Renal and cardiac function should be monitored and supportivt treatment should be directed at maintaining fluid and electrolyte balance and correcting hypo -glycarmia. Haemodialysis ana baemcperfusicn have been used with some success but peritoneal dialysis is ineffective.
Drug Interaction :
The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged rrgular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
Preqnancy & Lactation :
Human and animal studies have not identified any risk to pregnancy or embrvofcetat development, Human studies have not identified any risk to lactation or the breast-fed offspring. Paracetamol crosses the placental barrier and is excreted in breast milk
Precaution & Warnings :
Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazard of overdose: is greater in those with non-cirrhotic alcoholic ffver disease. Patients who are taking other potentially hepatotoxic drugs are at Increased risk of paracetamol-induced hepatotoxicity.
Package & Storage :
Tablets: Strips of 10 tablets in packs of 2 strips. Store below 30 C
Syrup: Bottle of 125ml
Suppository: Box of 5 suppositories,
Storage :
See outer pack,
Instruction to Patient :
– Do not exceed the stated dose
– D0 not to take other paracetamol-containing products concurrently.
– If symptoms persist consult your doctor.
– If you have been diagnosed with liver or kidney impairment seek medical advice before taking this medication
– KEEP ALL MEDICAMENTS OUT OF THE REACH OF CHILDREN
Manufactured by :
GlaxoSmithKline SAE.- El Salam city-Cairo- Egypt
For Suppositories: Manufactured by Smith Kline Beecham – Elharam-Giza for GlaxoSmithKline SAE. -Egypt